Nanoparticles in Cellular Drug Delivery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 5590
Special Issue Editors
Interests: mesoporous silica nanoparticles; drug formulation; 3D printing; tissue engineering; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Interests: theranostic nanoparticles; functional assembly; drug nanocarriers; nanocatalysts; combined therapy; nano-bio interfaces; stimuli responsiveness
Special Issue Information
Dear Colleagues,
Since the millennium shift, there has been an explosive development in the intracellular delivery of active agents, especially with the aid of nanoparticles (NPs). Diverse drug formulations have emerged by combining technologies of host–guest interactions, self-assembly, aggregation/clustering, encapsulation, loading, and so forth at molecular and nanometer scale. NPs can flexibly be designed to overcome the challenges associated with intracellular delivery, including crossing of the cell membrane, protection of sensitive agents during delivery, and the integration of controlled release functions into the carrier system. Drug action targets and activation pathways can be accessed/triggered more efficiently and specifically to realize precise therapy based on various mechanisms such as modification of biomacromolecules and their interaction networks, intervention of organelle functions, reprogramming of energy metabolism, remodeling of tumor microenvironment, reversion of immunosuppression, etc. The more recent surge in biological drugs (peptides, proteins, genes) in particular highlighted the importance of effective cellular delivery systems, boosted by the success of the Moderna and Pfizer/BioNTech COVID-19 nanovaccines. Moreover, the combination of externally applied energy and endogenous triggers is now frequently employed to further improve the selectivity of the NP-facilitated drug treatment or boost the therapeutic outcomes. Although many challenges have been solved, plenty remain—especially in view of the efficacy and translation of the more novel technologies.
This Special Issue is dedicated to presenting the recent advances relevant to Nanoparticles in Cellular Drug Delivery, ranging from synthesis methods and regulatory aspects to their detailed physicochemical characterization, interactions at the nano–bio interfaces, mechanisms of cell fate decisions, and performance in vitro and in vivo, especially for controlled and/or targeted drug delivery applications.
Prof. Dr. Jessica M. Rosenholm
Prof. Dr. Jixi Zhang
Guest Editors
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Keywords
- nanomedicine
- intracellular delivery
- controlled release
- cellular targeting
- delivery of biologicals
- gene transfection
- precision therapy
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