Plant Derived Natural Products and Age-Related Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 21892
Special Issue Editors
Interests: natural products; Alzheimer's disease; beta-amyloid; chromatography; cholinesterase enzymes; pharmacology; toxicology and pharmaceutics
Interests: medicinal chemistry; organic synthesis; natural products; Alzheimer's disease; metabolic disease; inflammatory diseases; neglected tropical diseases
Special Issue Information
Dear Colleagues,
Thanks to a continuous increase in life expectancy, the number of people aged 65 or older is sharply increasing, and it is estimated to approach 1.5 billion by 2050. Aging societies need to face unmet issues and propose solutions for a better quality of life of an increasingly aging population that encounters a higher risk of multiple health conditions and mobility problems. Age-related diseases are defined as diseases with incidence rates among the adult population increasing with age, and include dementia, Alzheimer's disease, diabetes, atherosclerosis, cardiovascular disease, arthritis, cataracts, osteoporosis, hypertension. These pathologies bring enormous social and economic burdens and can strongly impact the economic growth of a country.
The plant kingdom constitutes an important source of pharmacologically active compounds. Unmodified plant-derived natural products have a long history of therapeutic use in the most diverse areas, including age-associated diseases. In addition, natural products have served as templates for the design of derivatives with an improved therapeutic impact.
In this light, this Special Issue focuses on research works on naturally occurring compounds (primary and secondary metabolites) isolated from plants, chemically modified and purely synthetic structures which were conceptually derived from natural products. In more detail, this Special Issue will cover aspects related to (i) the design, synthesis and biological evaluation of compounds inspired by natural products, (ii) analytical approaches for the isolation and/or characterization of bioactive natural products; (iii) investigations on the mechanism of action of active plant metabolites either in vitro or in vivo; (iv) investigations on novel therapeutic targets modulated by natural products; (v) etnodirected drug discovery.
Prof. Dr. Manuela Bartolini
Prof. Dr. Luiz Antonio Soares Romeiro
Guest Editors
Keywords
- bioactive natural products
- active phytocomponent profiling
- synthesis
- semi-synthetic derivatives
- synthetic natural product derivatives
- bioguided fractionation
- mechanism elucidation
- etnodirected drug discovery
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