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Review

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

1
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
2
Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea
3
Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editors: Manuela Bartolini and Luiz Antonio Soares Romeiro
Molecules 2021, 26(17), 5327; https://doi.org/10.3390/molecules26175327
Received: 29 July 2021 / Revised: 25 August 2021 / Accepted: 27 August 2021 / Published: 2 September 2021
(This article belongs to the Special Issue Plant Derived Natural Products and Age-Related Diseases)
Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs. View Full-Text
Keywords: neurodegenerative diseases; natural products; alzheimer’s disease; parkinson’s disease; therapeutic potential; oxidative stress; neuroinflammation neurodegenerative diseases; natural products; alzheimer’s disease; parkinson’s disease; therapeutic potential; oxidative stress; neuroinflammation
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MDPI and ACS Style

Rahman, M.H.; Bajgai, J.; Fadriquela, A.; Sharma, S.; Trinh, T.T.; Akter, R.; Jeong, Y.J.; Goh, S.H.; Kim, C.-S.; Lee, K.-J. Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules 2021, 26, 5327. https://doi.org/10.3390/molecules26175327

AMA Style

Rahman MH, Bajgai J, Fadriquela A, Sharma S, Trinh TT, Akter R, Jeong YJ, Goh SH, Kim C-S, Lee K-J. Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules. 2021; 26(17):5327. https://doi.org/10.3390/molecules26175327

Chicago/Turabian Style

Rahman, Md. H., Johny Bajgai, Ailyn Fadriquela, Subham Sharma, Thuy T. Trinh, Rokeya Akter, Yun J. Jeong, Seong H. Goh, Cheol-Su Kim, and Kyu-Jae Lee. 2021. "Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges" Molecules 26, no. 17: 5327. https://doi.org/10.3390/molecules26175327

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