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Volume 26
Issue 18
10.3390/molecules26185441
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Review

Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease

by
Elisa Uliassi
1,
Andressa Souza de Oliveira
2,
Luciana de Camargo Nascente
2,
Luiz Antonio Soares Romeiro
2,* and
Maria Laura Bolognesi
1,*
1
Department of Pharmacy and Biotechnology, Alma Mater Studiorum—University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy
2
Department of Pharmacy, Health Sciences Faculty, Campus Universitário Darcy Ribeiro, University of Brasília, Brasília 70910-900, DF, Brazil
*
Authors to whom correspondence should be addressed.
Molecules 2021, 26(18), 5441; https://doi.org/10.3390/molecules26185441
Submission received: 2 August 2021 / Revised: 24 August 2021 / Accepted: 30 August 2021 / Published: 7 September 2021
(This article belongs to the Special Issue Plant Derived Natural Products and Age-Related Diseases)
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Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-AD drugs. Recently, a therapeutic strategy based on the exploitation of Brazilian biodiversity was set with the aim of discovering new disease-modifying and safe drugs for AD. In this review, we will illustrate our efforts in developing new molecules derived from Brazilian cashew nut shell liquid (CNSL), a natural oil and a byproduct of cashew nut food processing, with a high content of phenolic lipids. The rational modification of their structures has emerged as a successful medicinal chemistry approach to the development of novel anti-AD lead candidates. The biological profile of the newly developed CNSL derivatives towards validated AD targets will be discussed together with the role of these molecular targets in the context of AD pathogenesis.
Keywords: Alzheimer’s disease; natural products; cashew nut shell liquid; anacardic acid; cardanol; cardol Alzheimer’s disease; natural products; cashew nut shell liquid; anacardic acid; cardanol; cardol

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MDPI and ACS Style

Uliassi, E.; de Oliveira, A.S.; de Camargo Nascente, L.; Romeiro, L.A.S.; Bolognesi, M.L. Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease. Molecules 2021, 26, 5441. https://doi.org/10.3390/molecules26185441

AMA Style

Uliassi E, de Oliveira AS, de Camargo Nascente L, Romeiro LAS, Bolognesi ML. Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease. Molecules. 2021; 26(18):5441. https://doi.org/10.3390/molecules26185441

Chicago/Turabian Style

Uliassi, Elisa, Andressa Souza de Oliveira, Luciana de Camargo Nascente, Luiz Antonio Soares Romeiro, and Maria Laura Bolognesi. 2021. "Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease" Molecules 26, no. 18: 5441. https://doi.org/10.3390/molecules26185441

APA Style

Uliassi, E., de Oliveira, A. S., de Camargo Nascente, L., Romeiro, L. A. S., & Bolognesi, M. L. (2021). Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease. Molecules, 26(18), 5441. https://doi.org/10.3390/molecules26185441

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