Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.7
4.6
Journals
Molecules
Special Issues
Bioactive Natural Products from Microorganisms
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Bioactive Natural Products from Microorganisms

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 21447

Special Issue Editor

Dr. Rosa M. Durán-Patrón

E-Mail Website
Guest Editor
Department of Organic Chemistry, University of Cadiz, Puerto Real (Cadiz), Spain
Interests: natural products; bioactive molecules; secondary metabolism; biosynthesis; biotrasnformation of xenobiotics; phytopathogenic fungi; marine fungi

Special Issue Information

Dear Colleagues,

Microbial natural products are characterized by a wide spectrum of biological activities that ensure the adaptation of microorganism to their environment and that mediate their interactions with other organisms. Some of these natural products can be exploited as new drugs or lead compounds in the pharmaceutical, cosmetic, agrochemical, food industries, and others.

There is currently a resurgence of interest in the discovery of structurally novel bioactive compounds from natural sources, largely due to the fact that synthetic libraries have not produced the expected number of candidates for development by the pharmaceutical industry, as well as to the appearance of pathogens resistant to the drugs currently used.

This Special Issue is focused on both original research and review articles that cover the isolation and structural elucidation of new bioactive compounds from microorganism, including new techniques to induce silent biogenetic gene clusters that lead to the discovery of novel cryptic natural products. Evaluation of the biological activities of the novel compounds, their structure–activity relationship, and molecular mechanisms of action are welcomed.

Dr. Rosa M. Durán-Patrón
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural products
  • Microbial metabolites
  • Structural elucidation
  • Biological activities
  • Structure-activity relationships

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 3553 KiB  
Article
Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential
by Khorshed Alam, Md. Mahmudul Islam, Caiyun Li, Sharmin Sultana, Lin Zhong, Qiyao Shen, Guangle Yu, Jinfang Hao, Youming Zhang, Ruijuan Li and Aiying Li
Molecules 2021, 26(24), 7524; https://doi.org/10.3390/molecules26247524 - 12 Dec 2021
Cited by 13 | Viewed by 3683
Abstract
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important microorganisms. Though most species of Pseudomonas have a large [...] Read more.
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important microorganisms. Though most species of Pseudomonas have a large number of NP biosynthetic gene clusters (BGCs) in their genomes, it is difficult to link many of these BGCs with products under current laboratory conditions. In order to gain new insights into the diversity, distribution, and evolution of these BGCs in Pseudomonas for the discovery of unexplored NPs, we applied several bioinformatic programming approaches to characterize BGCs from Pseudomonas reference genome sequences available in public databases along with phylogenetic and genomic comparison. Our research revealed that most BGCs in the genomes of Pseudomonas species have a high diversity for NPs at the species and subspecies levels and built the correlation of species with BGC taxonomic ranges. These data will pave the way for the algorithmic detection of species- and subspecies-specific pathways for NP development. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Figure 1

9 pages, 884 KiB  
Article
Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
by Imran Khan, Jing Peng, Zhuangjie Fang, Wei Liu, Wenjun Zhang, Qingbo Zhang, Liang Ma, Guangtao Zhang, Changsheng Zhang and Haibo Zhang
Molecules 2021, 26(4), 1080; https://doi.org/10.3390/molecules26041080 - 18 Feb 2021
Cited by 6 | Viewed by 2622
Abstract
The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical [...] Read more.
The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Figure 1

14 pages, 4947 KiB  
Article
Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
by Alex J. Lee, Melissa M. Cadelis, Sang H. Kim, Simon Swift, Brent R. Copp and Silas G. Villas-Boas
Molecules 2020, 25(24), 5997; https://doi.org/10.3390/molecules25245997 - 18 Dec 2020
Cited by 15 | Viewed by 3143
Abstract
We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and [...] Read more.
We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A—a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV–Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Figure 1

10 pages, 1785 KiB  
Article
Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds
by Hitomi Sasaki, Yuzuru Kubohara, Hirotaka Ishigaki, Katsunori Takahashi, Hiromi Eguchi, Akihiro Sugawara, Yoshiteru Oshima and Haruhisa Kikuchi
Molecules 2020, 25(12), 2895; https://doi.org/10.3390/molecules25122895 - 23 Jun 2020
Cited by 5 | Viewed by 2436
Abstract
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by [...] Read more.
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

27 pages, 1691 KiB  
Review
Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi
by Yuanwei Liu, Kishneth Palaniveloo, Siti Aisyah Alias and Jaya Seelan Sathiya Seelan
Molecules 2021, 26(11), 3227; https://doi.org/10.3390/molecules26113227 - 27 May 2021
Cited by 9 | Viewed by 3748
Abstract
Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, [...] Read more.
Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Figure 1

17 pages, 1079 KiB  
Review
Strategies for Natural Products Discovery from Uncultured Microorganisms
by Khorshed Alam, Muhammad Nazeer Abbasi, Jinfang Hao, Youming Zhang and Aiying Li
Molecules 2021, 26(10), 2977; https://doi.org/10.3390/molecules26102977 - 17 May 2021
Cited by 8 | Viewed by 4829
Abstract
Microorganisms are highly regarded as a prominent source of natural products that have significant importance in many fields such as medicine, farming, environmental safety, and material production. Due to this, only tiny amounts of microorganisms can be cultivated under standard laboratory conditions, and [...] Read more.
Microorganisms are highly regarded as a prominent source of natural products that have significant importance in many fields such as medicine, farming, environmental safety, and material production. Due to this, only tiny amounts of microorganisms can be cultivated under standard laboratory conditions, and the bulk of microorganisms in the ecosystems are still unidentified, which restricts our knowledge of uncultured microbial metabolism. However, they could hypothetically provide a large collection of innovative natural products. Culture-independent metagenomics study has the ability to address core questions in the potential of NP production by cloning and analysis of microbial DNA derived directly from environmental samples. Latest advancements in next generation sequencing and genetic engineering tools for genome assembly have broadened the scope of metagenomics to offer perspectives into the life of uncultured microorganisms. In this review, we cover the methods of metagenomic library construction, and heterologous expression for the exploration and development of the environmental metabolome and focus on the function-based metagenomics, sequencing-based metagenomics, and single-cell metagenomics of uncultured microorganisms. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop