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Natural Ingredient-Based Cosmeceutical: Advances and Applications in Cosmetics Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 478

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Botany, Medical University of Lublin, 20-093 Lublin, Poland
Interests: phytochemicals; natural product chemistry; bioactivity; phytochemical analysis; extraction; biological activities; phenolic compounds; natural product isolation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
Interests: cosmetic formulation; natural products; skin microbiome; plant extracts; cosmeceuticals; stability of creams; pharmaceutical technology; dermatological applications; probiotics and prebiotics; innovative cosmetic ingredients

Special Issue Information

Dear Colleagues,

Natural ingredient-based cosmeceuticals represent one of the most dynamic and promising areas at the interface of cosmetic chemistry, dermatology, and pharmaceutical sciences. Bioactive compounds derived from plants, microorganisms, marine organisms, and biotechnological sources exhibit a wide spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, photoprotective, and anti-aging effects. Increasing evidence also highlights their potential to modulate the skin barrier and microbiome, contributing to holistic skin health.

The rapid evolution of advanced formulation technologies—such as nanocarriers, liposomes, hydrogels, and biopolymeric systems—enables the development of products with enhanced stability, targeted delivery, improved bioavailability, and proven safety profiles. These innovations are expanding the possibilities for translating natural bioactivities into effective, sustainable, and consumer-trusted cosmeceuticals.

In this Special Issue, we invite original research papers and comprehensive reviews covering:

  • Discovery of novel natural ingredients for cosmetic use;
  • Innovative extraction, purification, and characterization techniques;
  • Mechanistic studies on molecular pathways underlying bioactive functions;
  • Formulation strategies ensuring efficacy and safety;
  • Applications of natural actives in skin care, hair care, and multifunctional cosmetic products;
  • Studies on safety, toxicology, pharmacokinetics, and regulatory aspects of natural cosmeceuticals.

By integrating fundamental insights with technological advances, this issue aims to provide a comprehensive perspective on the current state and future directions of natural ingredient-based cosmeceuticals, fostering dialog between academia and industry to accelerate innovation in cosmetic chemistry.

Prof. Dr. Katarzyna Dos Santos Szewczyk
Guest Editor

Dr. Katarzyna Wojciechowska
Guest Editor Assistant

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural ingredients
  • cosmeceuticals
  • cosmetic chemistry
  • bioactive compounds
  • plant extracts
  • skin health
  • anti-aging
  • antioxidants
  • cosmetic formulation
  • innovative technologies in cosmetology
  • safety and toxicology
  • photoprotection
  • marine-derived actives
  • biopolymers
  • sustainable cosmetics
  • nano-delivery systems
  • dermal applications
  • functional skincare

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Published Papers (1 paper)

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Research

27 pages, 1462 KB  
Article
Psidium cattleyanum Sabine as a Source of Bioactive Compounds for Skin Disorders
by Izabela Bielecka, Katarzyna Wojciechowska, Katarzyna Klimek, Sebastian Granica, Małgorzata Karska-Miazga, Arlindo Rodrigues Fortes and Katarzyna Dos Santos Szewczyk
Molecules 2026, 31(4), 690; https://doi.org/10.3390/molecules31040690 - 17 Feb 2026
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Abstract
Psidium cattleyanum Sabine (strawberry guava, araçá) is an ethnomedicinal plant with reputed health benefits; however, its potential for treating skin disorders remains underexplored. This study aimed to characterize the phytochemical profile of P. cattleyanum leaves from Cabo Verde and evaluate their bioactivity relevant [...] Read more.
Psidium cattleyanum Sabine (strawberry guava, araçá) is an ethnomedicinal plant with reputed health benefits; however, its potential for treating skin disorders remains underexplored. This study aimed to characterize the phytochemical profile of P. cattleyanum leaves from Cabo Verde and evaluate their bioactivity relevant to skin health. Phytochemical analysis was performed using high-performance liquid chromatography-mass spectrometry (LC-MS) and spectrophotometric assays. Key biological activities were assessed in vitro, including antioxidant capacity (free radical scavenging assays), anti-aging enzyme inhibition (collagenase, elastase, and tyrosinase), and antibacterial activity against skin pathogens (agar diffusion, minimum inhibitory concentration, and combination studies with standard antibiotics). Cytotoxicity was evaluated using Vero cells (MTT assay). Additionally, a topical cream containing the leaf extract was formulated and subjected to physicochemical stability and sensory testing. LC-MS revealed a rich polyphenolic composition in the leaf extract, including abundant phenolic acids (gallic and ellagic acid derivatives) and flavonoid glycosides. The extract exhibited a high total phenolic content and strong antioxidant activity in DPPH/ABTS assays. It showed potent inhibition of collagenase, elastase, and tyrosinase, indicating an anti-aging effect against wrinkle formation and hyperpigmentation. The extract also demonstrated broad antimicrobial efficacy against skin-associated bacteria, such as Staphylococcus aureus and Cutibacterium acnes, with no antagonism and partial synergism observed when combined with certain antibiotics. The P. cattleyanum extract was successfully incorporated into a cream formulation that remained physically and chemically stable (no phase separation, consistent droplet size, and pH) over 90 days, with good homogeneity and acceptable sensory characteristics (neutral odor, smooth texture, and good spreadability). P. cattleyanum leaves from Cabo Verde are a rich source of bioactive compounds with multifunctional dermatological benefits. This study demonstrates that the P. cattleyanum leaf extract exhibits significant antioxidant, antimicrobial, and anti-aging activities in vitro, supporting its potential use as a natural ingredient for skin care. Full article
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