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Anti-Cancer and Anti-Inflammatory Activity of Medicinal Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 792

Special Issue Editor


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Guest Editor
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Interests: chemical biology; natural products; medicinal plants; biosynthesis; alkaloids; terpenes; anti-cancer activity; anti-inflammatory activity; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Medicinal plants represent an inexhaustible reservoir of active compounds exhibiting anti-cancer and anti-inflammatory properties, encompassing flavonoids, terpenes, phenolics, saponins, and numerous other unprecedented structural classes. Advances in modern science have facilitated the cellular-level examination of these naturally occurring compounds, enabling the modification of natural molecules to yield derivatives with enhanced activity or reduced toxicity. Furthermore, extensive research into their diverse pharmacological effects is now possible.

This Special Issue of Molecules will showcase the latest breakthroughs in isolating and identifying novel molecules, modifying known ones, and demonstrating the in vitro and in vivo efficacies of substances derived from medicinal plants with anti-cancer and anti-inflammatory potential. We invite authors to contribute original articles, communications, and comprehensive reviews on these topics.

Prof. Dr. Yingtong Di
Guest Editor

Manuscript Submission Information

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Keywords

  • medicinal plants
  • anti-cancer activity
  • anti-inflammatory activity
  • natural products
  • modification
  • derivatives
  • bioassay

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Published Papers (1 paper)

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Research

12 pages, 867 KB  
Article
Ingenane Diterpenoids from Euphorbia peplus: Structure Elucidation and Autophagic Flux Activation Activity
by Jiajia Wan, Qingyun Lu, Zifei Xu, Xiaojiang Hao, Rongcan Luo and Yingtong Di
Molecules 2026, 31(9), 1388; https://doi.org/10.3390/molecules31091388 - 23 Apr 2026
Viewed by 413
Abstract
Autophagy dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD), and enhancing autophagic flux has been proposed as a potential strategy for addressing neurodegenerative diseases. To expand the structural diversity of ingenol esters and systematically evaluate their autophagic flux activation activity, a [...] Read more.
Autophagy dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD), and enhancing autophagic flux has been proposed as a potential strategy for addressing neurodegenerative diseases. To expand the structural diversity of ingenol esters and systematically evaluate their autophagic flux activation activity, a systematic phytochemical investigation of ingenane diterpenoids from Euphorbia peplus was conducted. A total of 13 ingenane-type compounds were isolated and identified, including two previously undescribed compounds, euphingenol A and B (12), together with 11 known analogs (313). Their structures were elucidated by extensive spectroscopic analyses (HRESIMS and NMR) and comparison with literature data. The compounds were evaluated for their bioactivity with flow cytometry in assays of autophagic flux in HM Cherry-GFP-LC3 (human microglia cells stably expressing the tandem monomeric mCherry-GFP-tagged LC3) cells. 17-O-benzoyl-20-deoxyingenol (3) significantly activated autophagic flux at concentrations of 10 μM and 40 μM, while euphingenol A (1) induced a dose-dependent increase, with structure-activity relationship analysis indicating that C-17 acylation enhances this bioactivity. These findings suggest that compound 3 warrants further investigation as a potential modulator of autophagic flux, possibly through binding to PKCδ (protein kinase C), with relevance to autophagy-related neurodegenerative conditions. Full article
(This article belongs to the Special Issue Anti-Cancer and Anti-Inflammatory Activity of Medicinal Plants)
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