Drug Resistance in Targeted Cancer Therapy
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 November 2019) | Viewed by 14277
Special Issue Editors
Interests: molecular mechanisms of drug activity; anticancer drugs; targeted agents; drug resistance; pharmacogenetics; pancreatic cancer; lung cancer
Special Issues, Collections and Topics in MDPI journals
Interests: marine alkaloids; heterocycles; drug discovery; synthesis; bioactive compounds; antitumor activity; antibiofilm activity; and kinase inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
During the last decade, new and rationally designed drugs have been developed to neutralize specific molecules or genes involved in the development of cancer, appropriately called “targeted agents”. Most of these novel agents interact with receptors or signalling molecules, that are pivotal in tumor growth and development, and they can inhibit cancer cell proliferation, or induce programmed cell death. However, these drugs have been approved only for a limited number of malignancies, and further studies to evaluate novel applications, as well as identify biomarkers to guide these treatments are warranted. Similarly, new appropriate drug combinations might represent a major strategy to overcome the reasons for their failures, such as inherent or acquired resistance, in different tumor types.
The present issue deals with the pharmacology of the most promising compounds targeting the key oncogenic pathways implicated in the development and progression of many tumor types through multiple effects on cell cycle progression, apoptosis, and invasion. Remarkably, they use a highly overlapping repertoire of signalling adaptors and downstream pathways, and are potential targets for different drugs.
Therefore, this Special Issue will provide readers working in the basic biomedical sciences as well as clinicians a comprehensive overview of novel effective anticancer compounds, with the aim of clarifying their development, pharmacology, resistance factors, and new strategies and applications, against major tumors.
Prof. Dr. Elisa Giovannetti
Prof. Dr. Patricia Diana
Guest Editors
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Keywords
- anticancer drugs
- targeted agents
- drug resistance
- pharmacogenetics
- kinases
- drug discovery
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