DNA Topoisomerases: Structure, Function, Mechanism, and Regulation of Activities

Dear Colleagues,

DNA topoisomerases mediate changes in DNA topology. By relaxing and supercoiling DNA, by resolving or generating catenanes, or by introducing and removing knots, these enzymes resolve topological issues pertaining to DNA recombination, replication, and repair, as well as transcription, and maintain the topological state of DNA in the cell. Topoisomerases are grouped into different families according to common features in their structure and/or the mechanisms of the reaction they catalyze. However, structural and mechanistic insight gained in the past years has shown that there are a number of variations to these common themes, enabling the optimization of each enzyme for its physiological task, and allowing for species-specific variations and fine-tuning of activities. Genome-wide studies have defined the sites of topoisomerase binding to and action on DNA under physiological conditions, providing insights into cellular function and the regulation of their activities.

This Special Issue focuses on the structure, function, and mechanism of DNA topoisomerases and the regulation of their activities. Research articles report novel insights into specific aspects of DNA topoisomerases, while review articles highlight recent advances and summarize the current status of the field.

Prof. Dagmar Klostermeier
Guest Editor

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