Special Issue "DNA Topoisomerase: Structure, Function and Mechanism and Regulation of Activities"
Deadline for manuscript submissions: 31 December 2020.
Interests: topoisomerases; helicases; enzyme mechanism; single-molecule FRET; conformational changes
DNA topoisomerases mediate changes in DNA topology. By relaxing and supercoiling DNA, by resolving or generating catenanes, or by introducing and removing knots, these enzymes resolve topological issues pertaining to DNA recombination, replication, and repair, as well as transcription, and maintain the topological state of DNA in the cell. Topoisomerases are grouped into different families according to common features in their structure and/or the mechanisms of the reaction they catalyze. However, structural and mechanistic insight gained in the past years has shown that there are a number of variations to these common themes, enabling the optimization of each enzyme for its physiological task, and allowing for species-specific variations and fine-tuning of activities. Genome-wide studies have defined the sites of topoisomerase binding to and action on DNA under physiological conditions, providing insights into cellular function and the regulation of their activities.
This Special Issue focuses on the structure, function, and mechanism of DNA topoisomerases and the regulation of their activities. Research articles report novel insights into specific aspects of DNA topoisomerases, while review articles highlight recent advances and summarize the current status of the field.
Prof. Dagmar Klostermeier
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Topoisomerase structure
- Topoisomerase mechanism
- Regulation of topoisomerase activity