Countercurrent Chromatography (CCC/CPC) as Versatile Separation ‘Tool-Box’ in the Field of Natural Product Recovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 7512
Special Issue Editors
Interests: off-line/ on-line hyphenation of countercurrent (CCC) and Centrifugal Partition Chromatography (CPC) to structure elucidation method; two-dimensional metabolite analysis; food and medicinal plant analysis; structural elucidation of betacyanin pigments and saponins; evaluation of biological activities; natural products from agricultural residues
Special Issues, Collections and Topics in MDPI journals
Interests: structural elucidation of natural products using NMR and MS; separations of natural products using differents strategies such as CC, MPLC, HPLC, etc.; strucutre/activity studies using natural products as models; evaluation of biological activities
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since Dr. Yoichiro Ito (NIH, Bethesda, USA) introduced “the coil planet centrifuge” in 1966 (published in Nature), countercurrent chromatography and its related techniques have started to work at higher efficiencies using stronger and faster changing gravitation force fields. This technology was originally designed for the separation of human blood cells but then evolved rapidly to become a powerful fractionation tool in the field of recovery of bioactive natural products. The use of immiscible solvent mixtures that have been specifically designed for separation problems is one of the unique features of this methodology, whereby mobile and stationary chromatographic phases are in the liquid state.
Looking back at a development period spanning more than fifty years, many innovative CCC/CPC approaches have evolved, including powerful system designs For natural product chemists, there is the potential for the direct implementation of structural elucidation technology and of off- or on-line biological evaluation in bio-assay-guided fractionation protocols.
Therefore, this Special Issue will cover “Countercurrent chromatography (CCC/CPC) as versatile ‘tool-box’ in the field of natural product recovery” and will collect original research/ review articles dealing with innovative developments in this field.
Topics of interest include but are not limited to the following:
- CCC and CPC in natural product recovery (all biological sources);
- Recovery protocols and strategies for high value natural products;
- Bio-assay-guided isolation procedures;
- Off-line or on-line hyphenation to mass spectrometry (MS) and nuclear magnetic resonance (NMR);
- Two-dimensional CCC or CPC (heart-cutting), or CCC/CPC x GC x LC-MS;
- Polarity-modifying additives for solvent systems;
- Chiral additives for enantiomer/ epimer separations;
- Use of natural deep eutectic solvent systems (NADES);
- Software based prediction of natural product separations;
- Aqueous-two-phase-systems (ATPS);
- Ion exchange and ion-pair chromatography (IP);
- Green solvent systems for CCC/CPC;
- New CCC/CPC column and centrifuge designs for improved natural product recovery.
Something that is highly relevant is the combination of CCC/CPC with bio-assay-guided fractionation methods for the search of lead structures in the field of natural products from all kinds of resources, as nature is still the “Fountain for the Drugs of the Future”.
Overall, the present Special Issue aims to cover novel research directions in the field of natural product recovery using CCC and CPC technologies.
Dr. Gerold Jerz
Prof. Dr. João Henrique G. Lago
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CCC and CPC in natural product recovery (all biological sources)
- recovery protocols and strategies for high value natural products
- bio-assay-guided isolation procedures
- off-line or on-line hyphenation to mass spectrometry (MS) and nuclear magnetic resonance (NMR)
- two-dimensional CCC or CPC (heart-cutting), or CCC/CPC x GC x LC-MS
- polarity-modifying additives
- chiral additives for enantiomer/ epimer separations
- use of natural deep eutectic solvent systems (NADES)
- software based prediction of natural product separations
- aqueous-two-phase-systems (ATPS)
- ion exchange and ion-pair chromatography (IP)
- green solvent systems for CCC/CPC
- new CCC/CPC column and centrifuge designs for improved natural product recovery
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.