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Antibacterial Agents from Natural Source, 2nd Edition
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Antibacterial Agents from Natural Source, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 6097

Special Issue Editor

Prof. Dr. Carlos H. G. Martins

E-Mail Website
Guest Editor
Laboratory of Antimicrobial Testing, Federal University of Uberlândia, Uberlândia 38405-320, MG, Brazil
Interests: antibacterial activity; medicinal plants; biofilm; anaerobe; natural products; medicinal chemistry; bioactive compounds; anti-virulence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The golden age of antibiotics is now becoming something of the past. This is due to both the increase in bacterial resistance against antibiotics, and the decrease in the investment by pharmacologic industries in the search for new antibacterial products. In this scenario, the search for new targets and antibacterial compounds that can control infections through natural products has become extremely relevant to advances in the knowledge in this area.

The research of natural products with antibacterial potential, which aims to obtain active principles or chemical synthesis models to develop new drugs, has reflected the enormous interest of the scientific community in this field. Moreover, the research on the biodiversity of crude extracts, isolated compounds, and derived synthetics, amongst other products, obtained from vegetal species, animal venom (vertebrate and invertebrate), and minerals plays an important role due to the rich terrestrial diversity and abundant possible sources. Therefore, this kind of research deserves to be further deepened.

The variety of molecules found in natural products has been contributing to the treatment of infectious diseases and they are a valuable resource in terms of antibacterial control through products commercialized by the cosmetic, dentistry, food, and plague-control industries, among others.

This Special Issue of Molecules will be dedicated to the publication of original research and reviews of bioactive compounds obtained from natural products with antibacterial potential in their different forms of expression: chemical approaches, biologic assays (in vitro and in vivo), new targets, and anti-virulence and in silico studies. Papers that describe the development of new alternatives and action mechanism strategies or pharmacokinetics and pharmacodynamics of molecules obtained from natural products are also welcome.

Prof. Dr. Carlos H. G. Martins
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • antibacterial activity
  • anti-virulence
  • bioactive molecules
  • mechanisms and applications
  • biological activity
  • drug development
  • antibacterial peptides

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Related Special Issue

Published Papers (3 papers)

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Research

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10 pages, 1915 KiB  
Article
Abietane-Type Diterpenoids from the Arils of Torreya grandis
by Yuqi Gao, Jinghui Yang, Yue Zhang, Linlin Gao, Junmian Tian, Wenbo Han and Jinming Gao
Molecules 2024, 29(9), 1905; https://doi.org/10.3390/molecules29091905 - 23 Apr 2024
Viewed by 1335
Abstract
A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1–7) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by [...] Read more.
A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1–7) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds 5 and 6 had significant inhibitory effects on methicillin-resistant Staphylococcus aureus, with MIC values of 100 μM. Moreover, compounds 1, 3, 4, and 7 exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC50 values ranging from 38.4 to 67.9 μM. Full article
(This article belongs to the Special Issue Antibacterial Agents from Natural Source, 2nd Edition)
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25 pages, 1146 KiB  
Article
Phytochemical Profiles and Antimicrobial Activity of Selected Populus spp. Bud Extracts
by Piotr Okińczyc, Jarosław Widelski, Kinga Nowak, Sylwia Radwan, Maciej Włodarczyk, Piotr Marek Kuś, Katarzyna Susniak and Izabela Korona-Głowniak
Molecules 2024, 29(2), 437; https://doi.org/10.3390/molecules29020437 - 16 Jan 2024
Cited by 8 | Viewed by 2168
Abstract
Buds of poplar trees (Populus species) are often covered with sticky, usually polyphenol-rich, exudates. Moreover, accessible data showed that some Populus bud extracts may be excellent antibacterial agents, especially against Gram-positive bacteria. Due to the fragmentary nature of the data found, we [...] Read more.
Buds of poplar trees (Populus species) are often covered with sticky, usually polyphenol-rich, exudates. Moreover, accessible data showed that some Populus bud extracts may be excellent antibacterial agents, especially against Gram-positive bacteria. Due to the fragmentary nature of the data found, we conducted a systematic screening study. The antimicrobial activity of two extract types (semi-polar—ethanolic and polar—ethanolic-water (50/50; V/V)) from 27 bud samples of different poplar taxons were compared. Antimicrobial assays were performed against Gram-positive (five strains) and Gram-negative (six strains) bacteria as well as fungi (three strains) and covered the determination of minimal inhibitory, bactericidal, and fungicidal concentrations. The composition of extracts was later investigated by ultra-high-performance liquid chromatography coupled with ultraviolet detection (UHPLC-DAD) and with electrospray-quadrupole-time-of-flight tandem mass spectrometry (UHPLC-ESI-qTOF-MS). As a result, most of the extracts exhibited good (MIC ≤ 62.5 µg/mL) or moderate (62.5 < MIC ≤ 500 µg/mL) activity against Gram-positives and Helicobacter pylori, as well as fungi. The most active were ethanolic extracts from P. trichocarpa, P. trichocarpa clone ‘Robusta’, and P. tacamahaca × P. trichocarpa. The strongest activity was observed for P. tacamahaca × P. trichocarpa. Antibacterial activity was supposedly connected with the abundant presence of flavonoids (pinobanksin, pinobanksin 3-acetate, chrysin, pinocembrin, galangin, isosakuranetin dihydrochalcone, pinocembrin dihydrochalcone, and 2′,6′-dihydroxy-4′-methoxydihydrochalcone), hydroxycinnamic acids monoesters (p-methoxycinnamic acid cinnamyl ester, caffeic acid phenethylate and different isomers of prenyl esters), and some minor components (balsacones). Full article
(This article belongs to the Special Issue Antibacterial Agents from Natural Source, 2nd Edition)
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Review

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16 pages, 1519 KiB  
Review
The Role and Mechanisms of Antimicrobial Peptides in Overcoming Multidrug-Resistant Bacteria
by Jinhui Yang, Junning Zhang, Zeyu Feng and Yunqi Ma
Molecules 2025, 30(1), 128; https://doi.org/10.3390/molecules30010128 - 31 Dec 2024
Cited by 2 | Viewed by 1367
Abstract
Multidrug-resistant (MDR) bacteria are becoming more and more common, which presents a serious threat to world health and could eventually render many of the antibiotics we currently use useless. The research and development of innovative antimicrobial tactics that can defeat these hardy infections [...] Read more.
Multidrug-resistant (MDR) bacteria are becoming more and more common, which presents a serious threat to world health and could eventually render many of the antibiotics we currently use useless. The research and development of innovative antimicrobial tactics that can defeat these hardy infections are imperative in light of this predicament. Antimicrobial peptides (AMPs), which have attracted a lot of attention due to their distinct modes of action and capacity to elude conventional resistance mechanisms, are among the most promising of these tactics. As a promising substitute for conventional antibiotics, AMPs are a varied class of naturally occurring compounds that target bacteria membranes and disrupt cellular activities to demonstrate broad-spectrum antimicrobial activity. The objective of this study is to present a thorough summary of the current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, and possible synergy with currently used antimicrobial drugs. In addition, we define the review’s scope to include the most recent developments in AMP research, emphasizing the innovations’ development, optimization, and therapeutic promise. We hope to emphasize the crucial role that AMPs will play in the future of antimicrobial therapy by bringing together recent research and highlighting current issues. We also hope to advocate for AMPs’ continued research and development as part of a comprehensive strategy to counteract the growing threat of antibiotic resistance. Full article
(This article belongs to the Special Issue Antibacterial Agents from Natural Source, 2nd Edition)
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