Multicomponent Reactions for the Synthesis of Bioactive Heterocyclic Hybrids
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 15 November 2026 | Viewed by 252
Editors
Interests: multicomponent reaction; isocyanide; organic synthesis; chemoinformatic; molecular docking; heterocyclic synthesis
Interests: synthesis; organic synthesis; synthetic organic chemistry; medicinal and pharmaceutical chemistry; heterocyclic chemistry; organic chemistry; medicinal chemistry; cheminformatics and computational chemistry; 1h-nmr; docking
Special Issue Information
Dear Colleagues,
Multicomponent reactions (MCRs) have emerged as powerful and versatile synthetic tools for the rapid construction of structurally complex and functionally diverse molecules from simple building blocks in a single operational step under mild reaction conditions. Their intrinsic efficiency, convergence, atom economy, and compatibility with green chemistry principles make MCRs particularly attractive for modern medicinal chemistry and materials science. Concurrently, heterocyclic hybrids, which are molecular frameworks integrating two or more pharmacophoric fragments within a single scaffold, have attracted significant interest due to their capacity to modulate multiple biological targets, enhance pharmacokinetic properties, and address multifaceted diseases such as cancer, infectious diseases, and neurodegenerative disorders.
This Special Issue aims to highlight recent advances in the design, development, and application of multicomponent strategies for the synthesis of bioactive heterocyclic hybrids. Submissions addressing classical and emerging MCRs, such as Ugi, Passerini, Groebke–Blackburn–Bienaymé, and high-order MCRs, as well as post-MCR functionalization, diversity-oriented synthesis, mechanistic studies, and structure–activity relationship analyses, are particularly encouraged. This Special Issue will showcase how MCR platforms, particularly when coupled with post-condensation process (post-MCR), enable rapid access to biologically relevant, structurally complex heterocyclic hybrids while efficiently expanding and mapping drug-like chemical space.
Dr. Carlos J. Cortes-García
Dr. Luis Chacón
Guest Editors
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Keywords
- multicomponent reactions
- one-pot reactions
- molecular hybridization
- bioactive heterocycles
- drug discovery
- medicinal chemistry
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