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Molecules
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Nano-Based Drug Delivery and Diagnostics: Innovation and Applications
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Nano-Based Drug Delivery and Diagnostics: Innovation and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7950

Special Issue Editors

Dr. Jay Singh

E-Mail Website
Guest Editor
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India
Interests: energy storage devices; electrocatalytic/photocatalytic water splitting; sensors
Special Issues, Collections and Topics in MDPI journals
Dr. Ravindra Pratap Singh

E-Mail Website
Guest Editor
Department of Biotechnology, Faculty of Science, Indira Gandhi National Tribal University, Amarkantak 484886, Madhya Pradesh, India
Interests: biochemistry; biotechnology; nanobiotechnology; nanotechnology; biosensors
Dr. Natarajan Arunadevi

E-Mail Website
Guest Editor
Department of Chemistry, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India
Interests: chemistry; material chemistry; nanotechnology

Special Issue Information

Dear Colleagues,

Clinical science and technology play a combined role in taking advantage of the outstanding progress in the medical field to benefit humanity. Nanomaterial-based drug delivery and diagnostic approaches are where most cutting-edge research takes places in the field of nanotechnology, delivering versatile applications in the diagnosis and treatment of chronic and acute diseases with the aid of a target-oriented drug delivery mechanism and point-of-care (POC) detection strategy. Nano-based drug delivery and diagnostic strategies are expected to develop innovative therapies and diagnoses that can improve the current treatment procedure. It is important to highlight the new innovative technology and applications of drug delivery and diagnostic strategies. Hence, this Special Issue focuses on novel research in customized nanoparticles in the diagnosis, challenges of nanomedicines, and various clinical applications of nano-based materials.

Dr. Jay Singh
Dr. Ravindra Pratap Singh
Dr. Natarajan Arunadevi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • nano-based approaches
  • therapy
  • diagnostics
  • drug delivery
  • nanomedicine
  • targeted drug delivery
  • diagnostic approach

Published Papers (4 papers)

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Research

15 pages, 5268 KiB  
Article
Efficient pH-Responsive Nano-Drug Delivery System Based on Dynamic Boronic Acid/Ester Transformation
by Weijun Chen, Wanxuan Xie, Guangkuo Zhao and Qi Shuai
Molecules 2023, 28(11), 4461; https://doi.org/10.3390/molecules28114461 - 31 May 2023
Cited by 2 | Viewed by 1615
Abstract
Chemotherapy is currently one of the most widely used treatments for cancer. However, traditional chemotherapy drugs normally have poor tumor selectivity, leading to insufficient accumulation at the tumor site and high systemic cytotoxicity. To address this issue, we designed and prepared a boronic [...] Read more.
Chemotherapy is currently one of the most widely used treatments for cancer. However, traditional chemotherapy drugs normally have poor tumor selectivity, leading to insufficient accumulation at the tumor site and high systemic cytotoxicity. To address this issue, we designed and prepared a boronic acid/ester-based pH-responsive nano-drug delivery system that targets the acidic microenvironment of tumors. We synthesized hydrophobic polyesters with multiple pendent phenylboronic acid groups (PBA-PAL) and hydrophilic PEGs terminated with dopamine (mPEG-DA). These two types of polymers formed amphiphilic structures through phenylboronic ester linkages, which self-assembled to form stable PTX-loaded nanoparticles (PTX/PBA NPs) using the nanoprecipitation method. The resulting PTX/PBA NPs demonstrated excellent drug encapsulation efficiency and pH-triggered drug-release capacity. In vitro and in vivo evaluations of the anticancer activity of PTX/PBA NPs showed that they improved the pharmacokinetics of drugs and exhibited high anticancer activity while with low systemic toxicity. This novel phenylboronic acid/ester-based pH-responsive nano-drug delivery system can enhance the therapeutic effect of anticancer drugs and may have high potential for clinical transformations. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery and Diagnostics: Innovation and Applications)
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15 pages, 1848 KiB  
Article
Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model
by Saida S. Karshieva, Gulalek Babayeva, Vadim S. Pokrovsky, Yuri M. Shlyapnikov, Elena A. Shlyapnikova, Anna E. Bugrova, Alexey S. Kononikhin, Evgeny N. Nikolaev and Igor L. Kanev
Molecules 2023, 28(10), 4157; https://doi.org/10.3390/molecules28104157 - 18 May 2023
Cited by 1 | Viewed by 1723
Abstract
Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions. The aim of this work is to test the [...] Read more.
Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions. The aim of this work is to test the hypothesis that bleomycin nanoaerosol can be effectively used to treat multiple lung metastases. To obtain bleomycin nanoaerosol, an aerosol generator based on electrospray of a solution of a nonvolatile substance with gas-phase neutralization of charged aerosol particles was used. Lung metastases in murine Lewis lung carcinoma and B16 melanoma animal models were counted. The effect of inhaled bleomycin nanoparticles on the number and volume of metastases, as well as pulmonary side effects, was investigated. Using a mouse exposure chamber, the dose-dependent effect of inhaled bleomycin on tumor volume was evaluated in comparison with intraperitoneal administration. Bleomycin nanoaerosol reduced the volume of metastases and produced a higher antitumor effect at much lower doses. It has been established that long-term exposure to nanoaerosol with a low dose of bleomycin is capable of suppressing cancer cell growth. The treatment was well tolerated. In the lungs, minor changes were found in the form of focal-diffuse infiltration of the lung parenchyma. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery and Diagnostics: Innovation and Applications)
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25 pages, 1935 KiB  
Article
Enhanced Drug Delivery System Using Mesenchymal Stem Cells and Membrane-Coated Nanoparticles
by Shubham Joshi, Sarah Allabun, Stephen Ojo, Mohammed S. Alqahtani, Piyush Kumar Shukla, Mohamed Abbas, Chitapong Wechtaisong and Hussain M. Almohiy
Molecules 2023, 28(5), 2130; https://doi.org/10.3390/molecules28052130 - 24 Feb 2023
Cited by 3 | Viewed by 2129
Abstract
Mesenchymal stem cells (MSCs) have newly developed as a potential drug delivery system. MSC-based drug delivery systems (MSCs-DDS) have made significant strides in the treatment of several illnesses, as shown by a plethora of research. However, as this area of research rapidly develops, [...] Read more.
Mesenchymal stem cells (MSCs) have newly developed as a potential drug delivery system. MSC-based drug delivery systems (MSCs-DDS) have made significant strides in the treatment of several illnesses, as shown by a plethora of research. However, as this area of research rapidly develops, several issues with this delivery technique have emerged, most often as a result of its intrinsic limits. To increase the effectiveness and security of this system, several cutting-edge technologies are being developed concurrently. However, the advancement of MSC applicability in clinical practice is severely hampered by the absence of standardized methodologies for assessing cell safety, effectiveness, and biodistribution. In this work, the biodistribution and systemic safety of MSCs are highlighted as we assess the status of MSC-based cell therapy at this time. We also examine the underlying mechanisms of MSCs to better understand the risks of tumor initiation and propagation. Methods for MSC biodistribution are explored, as well as the pharmacokinetics and pharmacodynamics of cell therapies. We also highlight various promising technologies, such as nanotechnology, genome engineering technology, and biomimetic technology, to enhance MSC-DDS. For statistical analysis, we used analysis of variance (ANOVA), Kaplan Meier, and log-rank tests. In this work, we created a shared DDS medication distribution network using an extended enhanced optimization approach called enhanced particle swarm optimization (E-PSO). To identify the considerable untapped potential and highlight promising future research paths, we highlight the use of MSCs in gene delivery and medication, also membrane-coated MSC nanoparticles, for treatment and drug delivery. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery and Diagnostics: Innovation and Applications)
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16 pages, 2527 KiB  
Article
Silica Nanospheres Coated Silver Islands as an Effective Opto-Plasmonic SERS Active Platform for Rapid and Sensitive Detection of Prostate Cancer Biomarkers
by Anamika Pandey, Subhankar Sarkar, Sumit Kumar Pandey and Anchal Srivastava
Molecules 2022, 27(22), 7821; https://doi.org/10.3390/molecules27227821 - 13 Nov 2022
Cited by 3 | Viewed by 1538
Abstract
The in vitro diagnostics of cancer are not represented well yet, but the need for early-stage detection is undeniable. In recent decades, surface-enhanced Raman spectroscopy (SERS) has emerged as an efficient, adaptable, and unique technique for the detection of cancer molecules in their [...] Read more.
The in vitro diagnostics of cancer are not represented well yet, but the need for early-stage detection is undeniable. In recent decades, surface-enhanced Raman spectroscopy (SERS) has emerged as an efficient, adaptable, and unique technique for the detection of cancer molecules in their early stages. Herein, we demonstrate an opto-plasmonic hybrid structure for sensitive detection of the prostate cancer biomarker sarcosine using silica nanospheres coated silver nano-islands as a facile and efficient SERS active substrate. The SERS active platform has been developed via thin (5–15 nm) deposition of silver islands using a simple and cost-effective Radio Frequency (RF) sputtering technique followed by the synthesis and decoration of silica nanospheres (~500 nm) synthesized via Stober’s method. It is anticipated that the coupling of Whispering Gallery Modes and photonic nano-jets in SiO2 nanospheres induce Localized Surface Plasmon Resonance (LSPR) in Ag nano-islands, which is responsible for the SERS enhancement. The as-fabricated SERS active platform shows a linear response in the physiological range (10 nM to 100 μM) and an extremely low limit of detection (LOD) of 1.76 nM with a correlation coefficient of 0.98 and enhancement factor ~2 × 107. The findings suggest that our fabricated SERS platform could be potentially used for the rapid detection of bio-chemical traces with high sensitivity. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery and Diagnostics: Innovation and Applications)
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