Heterocyclic Compounds: Design, Synthesis and Pharmacological Activity
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 748
Special Issue Editors
Interests: organic chemistry; organic synthesis; biological activity; catalysis; structural elucidation by spectrometric techniques
Special Issue Information
Dear Colleagues,
Heterocyclic compounds represent one of the most significant classes in organic and medicinal chemistry, primarily because their ring systems contain heteroatoms such as nitrogen, oxygen, and sulfur, which impart unique structural and electronic properties to them. The rational design of these compounds relies on molecular modeling, combinatorial chemistry, and structural modifications aimed at enhancing their interaction with biological targets.
The synthetic approaches to heterocycles encompass both classical methods, such as condensation and cyclization, and modern strategies, including transition-metal-catalyzed reactions, multicomponent reactions, and sustainable methodologies involving green chemistry principles, heterogeneous catalysis, and ionic liquids.
From a pharmacological perspective, heterocyclic derivatives are fundamental scaffolds in drug discovery, exhibiting diverse biological activities such as anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant properties. Their structural diversity provides a versatile platform for the development of novel bioactive molecules with improved selectivity and potency.
In conclusion, the design, synthesis, and pharmacological evaluation of heterocyclic compounds remain a cornerstone of medicinal chemistry, combining synthetic innovation with therapeutic relevance.
Dr. Luciana Machado Ramos
Guest Editor
Dr. Aleksandar Pashev
Guest Editor Assistant
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Keywords
- heterocyclic compounds
- drug design
- multicomponent reactions
- green chemistry
- pharmacological activity
- medicinal chemistry
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