G Protein-Coupled Receptors (GPCR) in Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 25
Editors
Interests: neuropeptides; neuroinflammation; receptor pharmacology; migraine; mast cells; purinergic signaling
Special Issue Information
Dear Colleagues,
G protein-coupled receptors (GPCRs) constitute one of the largest families of membrane receptors and play essential roles in regulating numerous physiological and pathophysiological processes. Through receptor-mediated signaling pathways, GPCRs regulate diverse cellular events, including cell proliferation, apoptosis, inflammation, and metabolism. Consequently, GPCRs have emerged as one of the most important targets in modern drug discovery. Recent advances in structural biology, molecular pharmacology, computational approaches, and receptor signaling have greatly expanded our understanding of GPCR biology and accelerated the development of novel therapeutic strategies.
This Special Issue aims to highlight recent advances and emerging trends in GPCR research and their applications in drug discovery. Original research articles, short communications, and review articles are welcome.
Potential topics include, but are not limited to:
- GPCR structure and function;
- GPCR signaling pathways and molecular mechanisms;
- Ligand–receptor interactions;
- Biased agonism and allosteric modulation;
- GPCRs as therapeutic targets in human diseases;
- Novel drug candidates targeting GPCRs;
- Computational and structure-based drug design;
- Translational and preclinical studies involving GPCRs.
We look forward to receiving your valuable contributions.
Prof. Dr. Fatma Töre
Guest Editor
Dr. İlknur Birsen
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- G protein-coupled receptors (GPCRs)
- drug discovery
- cell signaling
- molecular pharmacology
- therapeutic targets
- structure-based drug design
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
