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Recent Advances in Total Synthesis of Natural Product

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1213

Special Issue Editor


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Guest Editor
School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China
Interests: biomimetic total synthesis; eco-friendly synthetic methodology

Special Issue Information

Dear Colleagues,

Today, biologically important natural products act as crucial starting points for drug discovery and potential sources of new medicines, along with being critical tools to learn about biologically important processes. Due to the low natural abundance and structural complexity of many bioactive natural products and their analogues, the ability to procure useful quantities of biologically important molecules by sustainable, scalable synthetic strategies is emerging as an important goal in synthetic chemistry. Approaches to naturally occurring molecules that yield substantial material enable collaborative investigations and eventual commercial production and inherently spur scientific development of eco-friendly catalytic systems for the synthesis of chemical entities of importance to society.

Dr. Xiao-Shui Peng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural product synthesis
  • biological evaluation
  • biomimetic
  • eco-friendly
  • catalytic

Published Papers (1 paper)

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Research

17 pages, 1595 KiB  
Article
Total Syntheses of Colletopeptide A and Colletotrichamide A
by Jing Chen, Yangyang Jiang, Jialei Yan, Chao Xu and Tao Ye
Molecules 2023, 28(20), 7194; https://doi.org/10.3390/molecules28207194 - 20 Oct 2023
Viewed by 954
Abstract
The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features asymmetric Brown crotylation, cross metathesis, Yamaguchi esterification, ozonolysis, and macrolactamization. A [...] Read more.
The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features asymmetric Brown crotylation, cross metathesis, Yamaguchi esterification, ozonolysis, and macrolactamization. A late-stage incorporation of the mannose fragment completed the synthesis of colletotrichamide A, and the desilylation of the common intermediate gave rise to colletopeptide A, which led to unambiguous confirmation of the absolute stereochemistry of the aforementioned natural products. Full article
(This article belongs to the Special Issue Recent Advances in Total Synthesis of Natural Product)
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