Nitrogen-Containing Heterocyclic Scaffolds: Synthesis and Bioactivity
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 759
Special Issue Editors
Interests: organic synthetic methodologies; supramolecular chemistry; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; organic synthesis; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocycles, particularly nitrogen-containing ones, are key structural motifs in drug discovery and development. Their widespread presence in pharmaceuticals is linked to their natural abundance in bioactive compounds, metabolic stability, and ability to form efficient interactions with biological targets. These features contribute to favorable pharmacokinetic and pharmacodynamic profiles, making heterocycles highly effective in modulating biological response.
Ongoing research aims to further enhance the efficiency, selectivity, and therapeutic potential of heterocyclic compounds. This multidisciplinary effort encompasses computational approaches (e.g. molecular docking, molecular dynamics), synthetic chemistry (including functionalization and scaffold diversification), and in-depth bioactivity studies.
By integrating synthetic innovation with biological insight, this Special Issue aims to highlight the central role of heterocycles in advancing modern therapeutics and welcomes contributions on all aspects of the medicinal chemistry of nitrogen-containing heterocyclic compounds. Topics may include the development of novel synthetic methodologies, exploration of structure–activity relationships, drug delivery strategies, and biological activity studies
Dr. Paolo Zardi
Dr. Alfonso Zambon
Guest Editors
Manuscript Submission Information
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Keywords
- heterocycles
- heteroaromatics
- drug discovery
- organic synthesis
- structure-activity relationship
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