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The Anticancer Drugs: A New Perspective

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 789

Special Issue Editors


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Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências da Universidade de Lisboa, 1749-016 Lisboa, Portugal
Interests: organometallic/inorganic chemistry; peptide chemistry; metal-peptide conjugates; interaction studies with biomolecules; anti-cancer drug design and development; drug delivery; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal
Interests: organic chemistry; medicinal chemistry; carbohydrate and nucleos(t)ide chemistry; bioactive molecules; enzyme inhibitors; anticancer agents; antimicrobial agents; anti-Alzheimer’s agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a serious issue that poses a significant threat to human health. In recent years, we have witnessed continuous progress in the development of anticancer drugs. Novel agents, ranging from small molecules to engineered antibodies and immune modulators, have been approved for use in cancer treatment. In addition, the toxic effects on normal, healthy cells could be minimized by developing drugs that specifically target cancer cells.

This Special Issue, entitled “The Anticancer Drugs: A New Perspective”, will present research that identifies and evaluates novel anticancer drugs and biological targets, and explores therapeutic approaches to the development of anticancer drugs. We therefore invite researchers working in this field to contribute original research articles and review articles.

Dr. Tânia S. Morais
Dr. Nuno Xavier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer therapy
  • targeted therapy
  • drug design
  • drug discovery
  • drug synthesis
  • nanotechnology

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Published Papers (1 paper)

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Research

21 pages, 2962 KiB  
Article
Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents
by Dóra Varga, Anna Szentirmai and András Szarka
Molecules 2025, 30(5), 1031; https://doi.org/10.3390/molecules30051031 - 24 Feb 2025
Viewed by 575
Abstract
Our research group aimed for the optimization of pharmacologic ascorbate (Ph-Asc)-induced cancer cell death. To reduce the required time and resources needed for development, an in silico system biological approach, an already approved medication, and a mild bioactive compound were used in our [...] Read more.
Our research group aimed for the optimization of pharmacologic ascorbate (Ph-Asc)-induced cancer cell death. To reduce the required time and resources needed for development, an in silico system biological approach, an already approved medication, and a mild bioactive compound were used in our previous studies. It was revealed that both Ph-Asc and resveratrol (RES) caused DSBs in the DNA, and chloroquine (CQ) treatment amplified the cytotoxic effect of both Ph-Asc and RES in an autophagy independent way. In the present study, we aimed at the further clarification of the cytotoxic mechanism of Ph-Asc, CQ, and RES by comparing their DNA damaging abilities, effects on the cells’ bioenergetic status, ROS, and lipid ROS generation abilities with those of the three currently investigated compounds (menadione, RSL3, H2O2). It could be assessed that the induction of DSBs is certainly a common point of their mechanism of action; furthermore, the observed cancer cell death due to the investigated treatments are independent of the bioenergetic status. Contrary to other investigated compounds, the DNA damaging effect of CQ seemed to be ROS independent. Surprisingly, the well-known ferroptosis inducer RSL3 was unable to induce lipid peroxidation in the pancreas ductal adenocarcinoma (PDAC) Mia PaCa-2 cell line. At the same time, it induced DSBs in the DNA, and the RSL3-induced cell death could not be suspended by the well-known ferroptosis inhibitors. All these observations suggest the ferroptosis resistance of this cell line. The observed DNA damaging effect of RSL3 definitely creates a new perspective in anticancer research. Full article
(This article belongs to the Special Issue The Anticancer Drugs: A New Perspective)
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