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Special Issue Editors

Dr. Sihua Hou

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Guest Editor

School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Interests: asymmetric synthesis of bioactive natural products; scale synthesis of natural medication molecules; target molecule-oriented novel and efficient synthesis methodology research; development of novel anti-tumor, anti-inflammatory and immunomodulatory drug candidates
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Yu Peng

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Guest Editor

School of Chemistry, Southwest Jiaotong University, Chengdu 610031, China
Interests: total synthesis; natural products; synthetic methodology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products are an important source of innovative drug discovery for their complex chemical structures and broad biological activities. The biosynthesis and chemical synthesis of natural products play a critical role in the development of new innovative drugs. Meanwhile, the synthesis of natural products is the most active field in organic synthesis and natural product chemistry. Recently, with the quick development of synthetic biology, the biosynthesis of natural products has achieved impressive achievement, which has also inspired organic chemists to develop novel synthetic methodologies and strategies toward the synthesis of bioactive natural products. Following on from these advances, this Special Issue, titled ‘Advances in the Biosynthesis and Chemical Synthesis of Natural Products’, invites the submission of research papers and reviews on the biosynthesis and chemical synthesis of natural products.

Dr. Sihua Hou
Prof. Dr. Yu Peng
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Research

16 pages, 2900 KiB

Open AccessArticle

Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase

by Long Yang, Liwei Yi, Bang Gong, Lili Chen, Miao Li, Xiangcheng Zhu, Yanwen Duan and Yong Huang

Molecules 2024, 29(9), 1982; https://doi.org/10.3390/molecules29091982 - 25 Apr 2024

Viewed by 314

Abstract

Chalkophomycin is a novel chalkophore with antibiotic activities isolated from Streptomyces sp. CB00271, while its potential in studying cellular copper homeostasis makes it an important probe and drug lead. The constellation of N-hydroxylpyrrole, 2H-oxazoline, diazeniumdiolate, and methoxypyrrolinone functional groups into one compact molecular architecture capable of coordinating cupric ions draws interest to unprecedented enzymology responsible for chalkophomycin biosynthesis. To elucidate the biosynthetic machinery for chalkophomycin production, the chm biosynthetic gene cluster from S. sp. CB00271 was identified, and its involvement in chalkophomycin biosynthesis was confirmed by gene replacement. The chm cluster was localized to a ~31 kb DNA region, consisting of 19 open reading frames that encode five nonribosomal peptide synthetases (ChmHIJLO), one modular polyketide synthase (ChmP), six tailoring enzymes (ChmFGMNQR), two regulatory proteins (ChmAB), and four resistance proteins (ChmA′CDE). A model for chalkophomycin biosynthesis is proposed based on functional assignments from sequence analysis and structure modelling, and is further supported by analogy to over 100 chm-type gene clusters in public databases. Our studies thus set the stage to fully investigate chalkophomycin biosynthesis and to engineer chalkophomycin analogues through a synthetic biology approach. Full article

(This article belongs to the Special Issue Advances in the Biosynthesis and Chemical Synthesis of Natural Products)

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