Synthesis, Enzyme Inhibitory Potential and Molecular Docking Study of Different Heterocycles
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2784
Special Issue Editor
Special Issue Information
Dear Colleagues,
Enzymes are essential biomolecules that exist in all living organism and are relevant to the catabolic and anabolic pathways. However, it is well known that altering the activity of certain enzymes may be involved in the onset of specific human diseases. Enzyme activity inhibition a promising approach for treating certain human diseases. For example, thrombin plays a vital role in the thrombosis process, and its inhibitors can be used to treat cardiovascular diseases. Glycosidase inhibitors have the potential to be used as drugs to treat hereditary lysosomal storage diereses, cancer, viral infection, and diabetes. Moreover, trypsin inhibitors can be used for the treatment of rheumatoid arthritis, hypertension, diabetes, and severe acute pancreatitis. The main approach to gout treatment is the inhibition of xanthine oxidase activity. Tyrosinase inhibitors can be used as potential drugs for the treatment of skin tumors and melanoma.
Heterocycles are common scaffolds, the vast majority of which are marketed as drugs and drug candidates. Heterocycles are the key to biological activity in several small drug molecules due to their capacity to form hydrogen bonds, change polarity, and modulate lipophilicity at particular sites in the host or pathogen, with the overall effect of inhibiting the biological processes that result in the programed progression of diseases. These subunits have the ability to enhance the physiochemical, toxicological, pharmacokinetic, and pharmacological properties of compounds, enhancing their effect in easing a variety of afflictions. New developments in synthetic techniques that result in rapid access to a wide range of heterocyclic compounds are of critical importance for medicinal chemists to quickly synthesize a large number of desired compounds to find novel and effective pharmaceuticals among heterocyclic compounds.
This Special Issue titled " Synthesis, enzyme inhibitory potential and molecular docking study of different heterocycles" will include research articles focusing on those enzymes whose overexpression is considered harmful to human health. The research articles will report both the identification of new enzymatic inhibitors that are potentially useful as well as drugs and the characterization of the mechanisms of action of new and already known enzyme inhibitors at in vitro or in vivo level.
Dr. Fazal Rahim
Guest Editor
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Keywords
- synthesis
- heterocycles
- enzymes
- molecular docking
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