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The Preparations and Applications of Organophosphorus Compounds
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The Preparations and Applications of Organophosphorus Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 1277

Special Issue Editors

Prof. Dr. K. Michał Pietrusiewicz

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Guest Editor
Department of Organic Chemistry and Crystallochemistry, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Sklodowska University, Lublin, Poland
Interests: organic synthesis and stereochemistry; phospine-borane chemistry; C-P heterocycles: synthesis and resolutions; P-stereogenic compounds: synthesis and use in asymmetric catalysis; chemo- and stereoselective P=O reductions; organometalic chemistry
Prof. Dr. Oleh Demchuk

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Guest Editor
Centre for Interdisciplinary Research, Faculty of Science and Health, The John Paul II Catholic University of Lublin, Lublin, Poland
Interests: organic synthesis; catalysis; transition metals; biologically active compounds; drug design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Organophosphorus compounds are not only indispensable substances to maintain the normal existence of life but also have a wide range of applications in nucleic acids, coenzymes, organophosphorus nerve gases, organophosphorus insecticides, organophosphorus fungicides, organophosphorus herbicides, chemotherapeutic agents, plasticizers, antioxidants, surfactants, complexants, organophosphorus extractants, flotation agents, flame retardants and more.

This Special Issue entitled "The Preparations and Applications of Organophosphorus Compounds" aims to present all aspects of the current original research, from synthetic methodology to catalysis, and from materials to biologically active compounds. It is my great pleasure to invite experts in the field of organophosphorus chemistry to submit manuscripts in the form of articles and comprehensive reviews to this Special Issue.

Prof. Dr. K. Michał Pietrusiewicz
Prof. Dr. Oleh Demchuk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organophosphorus chemistry
  • organophosphorus compounds
  • phosphorus-containing heterocycles
  • reactivity of organophosphorus compounds
  • phosphorus-based organocatalysis
  • phosphorus-containing drugs
  • structure elucidation of organophosphorus compounds

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Published Papers (1 paper)

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Research

18 pages, 7621 KiB  
Article
The Synthesis, Crystal Structure, Modification, and Cytotoxic Activity of α-Hydroxy-Alkylphosphonates
by Zsuzsanna Szalai, Anna Sára Kis, Angéla Takács, László Kőhidai, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos and György Keglevich
Molecules 2025, 30(2), 428; https://doi.org/10.3390/molecules30020428 - 20 Jan 2025
Viewed by 837
Abstract
A series of α-hydroxy-alkylphosphonates and α-hydroxy-alkylphosphine oxides were synthesized by the Pudovik reaction of acetaldehyde and acetone with dialkyl phosphites or diarylphosphine oxides. The additions were performed in three different ways: in liquid phase using triethylamine as the catalyst (1), on the surface [...] Read more.
A series of α-hydroxy-alkylphosphonates and α-hydroxy-alkylphosphine oxides were synthesized by the Pudovik reaction of acetaldehyde and acetone with dialkyl phosphites or diarylphosphine oxides. The additions were performed in three different ways: in liquid phase using triethylamine as the catalyst (1), on the surface of Al2O3/KF solid catalyst (2), or by a MW-assisted Na2CO3-catalyzed procedure (3). In most of the cases, our methods were more efficient and more robust than those applied in the literature. Two of the α-hydroxy-alkylphosphonates were subjected to single-crystal X-ray analysis, suggesting a dimeric and a chain supramolecular buildup in their respective crystals. Four α-hydroxy-alkylphosphonates and one α-hydroxy-ethylphosphine oxide were reacted with different acid chlorides to afford ten α-acyloxyphosphonates. Diethyl α-hydroxy-ethylphosphonate was transformed to the methanesulfonyloxy derivative that was useful in the Michaelis–Arbuzov reaction with triethyl phosphite and ethyl diphenylphosphinite to afford tetraethyl ethylidenebisphosphonate and diethyl α-(diphenylphosphinoyl)-ethylphosphonate, respectively. The α-hydroxyphosphonates and α-hydroxyphosphine oxides prepared were subjected to bioactivity studies, and the compounds tested exhibited limited cytotoxic effects on U266 cells with modest reductions in viability at a concentration of 100 μM. Full article
(This article belongs to the Special Issue The Preparations and Applications of Organophosphorus Compounds)
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