Innovative Analytical Approaches for the Isolation and Characterization of Drugs, Metabolites and Natural Bioactive Compounds

Dear Colleagues,

From pharmaceuticals and metabolites to plant bioactive compounds, innovative analytical, separation, and isolation methods and protocols represent essential pathways toward future advancements in chemistry and life sciences. This Special Issue focuses on emerging analytical techniques and methodological innovations that contribute towards the isolation, identification, and quantification of drugs, metabolites, and natural bioactive compounds, improving our understanding of their bioactivity, pharmacokinetics, and metabolic profiles.

The objectives of this Special Issue are to promote novel separation, isolation, and analytical methodologies, highlight the applications of advanced analytical techniques (e.g., LC-MS, GC-MS, LC-MS/MS, GC-MS/MS, NMR, FT-IR), and encourage sustainable and green analytical workflows.

We invite the submission of original research papers and reviews focused on innovative methodologies for the extraction, isolation, characterization, and chemical analysis of drugs, metabolites, and natural bioactive compounds. Contributions that focus on innovative analytical protocols and green and sustainable methodologies are particularly encouraged to be submitted to this Special Issue.

This Special Issue invites articles focused on, but not limited to, the following topics:

• Green and sustainable methodologies for the separation and isolation of active ingredients and natural bioactive phytochemicals;
• Novel chromatographic methods for the determination of drugs, metabolites, and bioactive compounds;
• Ultrasound/microwave-assisted extraction protocols, supercritical CO₂, and pressurized liquid extraction;
• Solvent-saving, miniaturized extraction protocols (e.g., solid-phase micro-extraction, microfluidic SPE) that boost the recovery of trace drugs, metabolites, and natural products in complex matrices;
• Metabolomic approaches for the discovery of biomarkers.

Dr. Evroula Hapeshi
Dr. Magda Psichoudaki
Guest Editors

Manuscript Submission Information

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