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Micromachines
Special Issues
Optofluidic Approach for Molecular Analysis
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Optofluidic Approach for Molecular Analysis

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 4497

Special Issue Editor

Prof. Dr. Christian Karnutsch

E-Mail Website
Guest Editor
Integrated Optofluidics and Nanophotonics (IONAS), Faculty of Electrical Engineering and Information Technology, Karlsruhe University of Applied Sciences, 76133 Karlsruhe, Germany
Interests: optofluidics; organic semiconductor lasers; absorption spectroscopy; lab-on-a-chip; blood analysis

Special Issue Information

Dear Colleagues,

A new field of research that has attracted considerable interest in the last decade is optofluidics, which integrates microfluidic and optical elements on the micrometre scale for widespread applications in fundamental sciences and engineering. Combining microfluidics and integrated photonic circuits enables devices that can carry analytes in microchannels to be probed by light, or, conversely, a fluid can modulate a photonic device. Optical phenomena are often used for molecular analysis needed in fields such as medical, chemical, and environmental analysis because they are harmless to the analyte and avoid interference from electrical and magnetic circuits of surrounding peripheral devices. Furthermore, optofluidic sensors offer attractive advantages, such as low reagent and sample consumption, relatively easy detection of molecular interactions as well as high processing speeds and precision. With the growing trend towards mass-producible and disposable sensing devices, optofluidic sensor chips have gained great interest due to low-cost, rapid and flexible processing that may allow for single-use, disposable items.

The aim of this Special Issue of Micromachines is to present research papers and review articles showing the most recent advances in the field of optofluidic sensing and analysis, including fundamental technologies, sciences, and applications.

Prof. Dr. Christian Karnutsch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical analysis
  • environmental analysis
  • molecular analysis
  • microfluidics
  • optofluidics
  • organic laser
  • organic semiconductor laser
  • absorption spectroscopy
  • lab-on-a-chip
  • food safety
  • chemistry
  • health care

Published Papers (2 papers)

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Research

16 pages, 3990 KiB  
Article
Colorimetric Phosphate Detection Using Organic DFB Laser Based Absorption Spectroscopy
by Thilo Pudleiner, Elias Sutter, Jörg Knyrim and Christian Karnutsch
Micromachines 2021, 12(12), 1492; https://doi.org/10.3390/mi12121492 - 30 Nov 2021
Cited by 1 | Viewed by 2086
Abstract
A novel compact laser absorption spectrometer is developed for colorimetric detection. We demonstrate the realization of the system as well as example measurements of phosphate in water samples based on the malachite green (MG) method. A phosphate concentration range of [...] Read more.
A novel compact laser absorption spectrometer is developed for colorimetric detection. We demonstrate the realization of the system as well as example measurements of phosphate in water samples based on the malachite green (MG) method. A phosphate concentration range of 1 mg/L to 31.25 μg/L (which corresponds to a molar concentration range of 10.5 μmol/L to 329 nmol/L) is investigated. This photometer demonstrates the ease of integration of organic distributed feedback (DFB) lasers and their miniaturizability, leading the way toward optofluidic on-chip absorption spectrometers. We constructed an optically pumped organic second-order DFB laser on a transparent substrate, including a transparent encapsulation layer, to have access to both emission directions of the surface-emitting laser. Using the two different surface emission directions of the laser resonator allows monitoring of the emitted light intensity without using additional optical elements. Based on these advances, it is possible to miniaturize the measurement setup of a laser absorption spectrometer and to measure analytes, such as phosphate. Full article
(This article belongs to the Special Issue Optofluidic Approach for Molecular Analysis)
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16 pages, 2792 KiB  
Article
Simultaneous Detection of Viability and Concentration of Microalgae Cells Based on Chlorophyll Fluorescence and Bright Field Dual Imaging
by Yanjuan Wang, Junsheng Wang, Tianqi Wang and Chengxiao Wang
Micromachines 2021, 12(8), 896; https://doi.org/10.3390/mi12080896 - 29 Jul 2021
Cited by 3 | Viewed by 1841
Abstract
Ship ballast water contains high concentration of plankton, bacteria, and other microorganisms. If the huge amount of ballast water is discharged without being inactivated, it will definitely spell disaster to the marine environment. Microalgae is the most common species exiting in ballast water, [...] Read more.
Ship ballast water contains high concentration of plankton, bacteria, and other microorganisms. If the huge amount of ballast water is discharged without being inactivated, it will definitely spell disaster to the marine environment. Microalgae is the most common species exiting in ballast water, so the detection of the concentration and viability of microalgae is a very important issue. The traditional methods of detecting microalgae in ballast water were costly and need the help of bulky equipment. Herein, a novel method based on microalgae cell intracellular chlorophyll fluorescence (CF) imaging combines with cell bright field (BF) microscopy was proposed. The geometric features of microalgae cells were obtained by BF image, and the cell viability was obtained by CF image. The two images were fused through the classic image registration algorithm to achieve simultaneous detection of the viability and concentration of microalgae cells. Furthermore, a low-cost, miniaturized CF/BF microscopy imaging prototype system based on the above principles was designed. In order to verify the effectiveness of the proposed method, four typical microalgae in ballast water (Platymonas, Pyramimonas sp., Chrysophyta, and Prorocentrum lima) were selected as the samples. The experimental results show that the self-developed prototype can quickly and accurately determine the concentration and the viability of microalgae cells in ship ballast water based on the dual images of BF and CF, and the detection accuracy is equivalent to that of commercial microscope. It was the first time to simultaneously detect the viability and concentration of microalgae cells in ship ballast water using the method that combining the fluorescence and bright field images; moreover, a miniaturized microscopic imaging prototype was developed. Those findings expected to contribute to the microalgae detection and ship ballast water management. Full article
(This article belongs to the Special Issue Optofluidic Approach for Molecular Analysis)
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