Microfluidic Machinery with 3D Channel Networks

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C1: Micro/Nanoscale Electrokinetics".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1026

Special Issue Editor


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Guest Editor
School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea
Interests: microfluidic machinery; microelectronics; bio-MEMS

Special Issue Information

Dear Colleagues,

Microfluidics has revolutionized biomedical, material, and chemical sciences by enabling the precise control of fluids at the micro- and nanoscale. While traditional 2D microfluidic systems have driven integration and miniaturization, their planar constraints limit their potential in complex fluidic networks and biomimetic environments.

The advent of microfluidic machinery with three-dimensional (3D) channel networks is pushing the boundaries of the field, enabling enhanced spatial control, higher throughput, and novel physicochemical interactions. These advancements are unlocking new possibilities for dynamic fluid manipulation, high-efficiency processing, and next-generation lab-on-a-chip technologies.

This Special Issue highlights innovative developments in 3D microfluidic machinery, with a focus on the following research areas:

  • New fabrication techniques for 3D micro- and nanochannel networks;
  • Breakthrough materials enabling advanced microfluidic architectures;
  • Novel 3D microfluidic experimental and analytical tools for biological and chemical applications;
  • Unprecedented fluidic phenomena observed in 3D space.

We welcome articles, reviews, and communications that explore the latest breakthroughs in 3D microfluidic machinery, from fundamental studies to real-world applications. Join us in shaping the future of microfluidics!

Dr. Juyeol Bae
Guest Editor

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Keywords

  • 3D microfluidics
  • microsystems
  • lab-on-a-chip
  • microfabrication
  • nanofabrication
  • high-throughput processing
  • biomimetics

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Published Papers (1 paper)

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Research

15 pages, 3631 KB  
Article
Parameter Optimization for High-Resolution Microfluidic Channel Fabrication Using a Commercial Low-Cost MSLA Printer
by Jintao Liu, Jiadong Ma, Jaeseon Kim and Juyeol Bae
Micromachines 2026, 17(2), 236; https://doi.org/10.3390/mi17020236 - 11 Feb 2026
Viewed by 688
Abstract
Vat polymerization-based 3D printing has emerged as a promising approach for the rapid, low-cost, and scalable fabrication of microfluidic devices; however, achieving high-resolution and fully clog-free microchannels using commercial resins remains challenging. In this study, we systematically investigate key printing parameters—including channel orientation, [...] Read more.
Vat polymerization-based 3D printing has emerged as a promising approach for the rapid, low-cost, and scalable fabrication of microfluidic devices; however, achieving high-resolution and fully clog-free microchannels using commercial resins remains challenging. In this study, we systematically investigate key printing parameters—including channel orientation, length, layer thickness, and exposure time—to elucidate their effects on channel openness, dimensional fidelity, and surface morphology using a commercially available low-cost masked stereolithography (MSLA) printer and printing resin, thereby establishing quantitative fabrication boundaries that define the transition from fully open to blocked microchannels in practice. Under optimized printing conditions, microchannels with characteristic dimensions exceeding 200 µm were fabricated in a reliable and clog-free manner using standard commercial resins. In addition, by implementing a size-compensated design strategy, we achieved the fabrication of complex droplet generator arrays with a minimum central channel width of 400 µm, while maintaining an internal dimensional deviation below 2.5%. These investigations significantly expand the practical applicability of low-cost MSLA 3D printing for microfluidic device fabrication, providing a scalable and accessible pathway for producing high-fidelity microchannels without reliance on custom resins or post-processing-intensive workflows. Full article
(This article belongs to the Special Issue Microfluidic Machinery with 3D Channel Networks)
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