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Micromachines
Special Issues
Advanced Biomaterials and Biofabrication
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Advanced Biomaterials and Biofabrication

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B2: Biofabrication and Tissue Engineering".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2584

Special Issue Editors

Dr. Yongcong Fang

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Interests: 3D bioprinting; regenerative medicine; cardiac tissue engineering; bioelectronics
Special Issues, Collections and Topics in MDPI journals
Dr. Zhongwei Guo

E-Mail Website
Guest Editor
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China
Interests: biomaterials; hydrogels; actuators; 3D bio-printing; tissue engineering
Dr. Kai Zheng

E-Mail Website
Guest Editor
Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China
Interests: bioactive glasses; composite hydrogels; coating; nanoparticles; tissue regeneration; additive manufacturing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A variety of biomaterials, including hydrogels, bioceramics, and polypeptides, have been widely used in biomedical applications, such as bioadhesives, bioelectronics, medical implants, organ-on-chips, and drug delivery systems. The design and fabrication of predictive structures and functions are essential for the development of advanced biomaterials. It is most effective to realize the targeted composition–structure–function relationship using advanced biofabrication technologies, such as micropatterning, electrospinning, and 3D bioprinting. In light of this, there is a high demand for versatile biomaterials as well as novel biofabrication technologies, which in turn leads to new opportunities in bio-design, biomimetics, and regenerative applications.

In this perspective, this Special Issue aims to publish research articles, short communications, and topical reviews focusing on innovative biomaterials and biofabrication technologies for biomedical applications. Some relevant topics include, but are not limited to:

  • The development of novel biomaterials (e.g., dynamic hydrogels, double network hydrogels, bioactive glasses, and biodegradable metals) for biomedical applications;
  • Innovation in 3D bioprinting and other biofabrication technologies;
  • Applications of biomaterials and biofabrication (e.g., tissue engineering, drug screening, disease modeling, bioadhesives, organ-on-a-chip, bioelectronics, and other related applications).

We look forward to receiving your submissions.

Dr. Yongcong Fang
Dr. Zhongwei Guo
Dr. Kai Zheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biofabrication
  • 3D bioprinting
  • tissue engineering
  • stem cell

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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22 pages, 3894 KiB  
Article
3D-Printed Biocompatible Frames for Electrospun Nanofiber Membranes: An Enabling Biofabrication Technology for Three-Dimensional Tissue Models and Engineered Cell Culture Platforms
by Adam J. Jones, Lauren A. Carothers, Finley Paez, Yanhao Dong, Ronald A. Zeszut and Russell Kirk Pirlo
Micromachines 2025, 16(8), 887; https://doi.org/10.3390/mi16080887 - 30 Jul 2025
Viewed by 82
Abstract
Electrospun nanofiber membranes (ESNFMs) are exceptional biomaterials for tissue engineering, closely mimicking the native extracellular matrix. However, their inherent fragility poses significant handling, processing, and integration challenges, limiting their widespread application in advanced 3D tissue models and biofabricated devices. This study introduces a [...] Read more.
Electrospun nanofiber membranes (ESNFMs) are exceptional biomaterials for tissue engineering, closely mimicking the native extracellular matrix. However, their inherent fragility poses significant handling, processing, and integration challenges, limiting their widespread application in advanced 3D tissue models and biofabricated devices. This study introduces a novel and on-mat framing technique utilizing extrusion-based printing of a UV-curable biocompatible resin (Biotough D90 MF) to create rigid, integrated support structures directly on chitosan–polyethylene oxide (PEO) ESNFMs. We demonstrate fabrication of these circular frames via precise 3D printing and a simpler manual stamping method, achieving robust mechanical stabilization that enables routine laboratory manipulation without membrane damage. The resulting framed ESNFMs maintain structural integrity during subsequent processing and exhibit excellent biocompatibility in standardized extract assays (116.5 ± 12.2% normalized cellular response with optimized processing) and acceptable performance in direct contact evaluations (up to 78.2 ± 32.4% viability in the optimal configuration). Temporal assessment revealed characteristic cellular adaptation dynamics on nanofiber substrates, emphasizing the importance of extended evaluation periods for accurate biocompatibility determination of three-dimensional scaffolds. This innovative biofabrication approach overcomes critical limitations of previous handling methods, transforming delicate ESNFMs into robust, easy-to-use components for reliable integration into complex cell culture applications, barrier tissue models, and engineered systems. Full article
(This article belongs to the Special Issue Advanced Biomaterials and Biofabrication)
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18 pages, 5887 KiB  
Article
Investigation of Liquid Collagen Ink for Three-Dimensional Printing
by Colten L. Snider, Chris J. Glover, David A. Grant and Sheila A. Grant
Micromachines 2024, 15(4), 490; https://doi.org/10.3390/mi15040490 - 2 Apr 2024
Cited by 3 | Viewed by 1872
Abstract
Three-dimensional printing provides more versatility in the fabrication of scaffold materials for hard and soft tissue replacement, but a critical component is the ink. The ink solution should be biocompatible, stable, and able to maintain scaffold shape, size, and function once printed. This [...] Read more.
Three-dimensional printing provides more versatility in the fabrication of scaffold materials for hard and soft tissue replacement, but a critical component is the ink. The ink solution should be biocompatible, stable, and able to maintain scaffold shape, size, and function once printed. This paper describes the development of a collagen ink that remains in a liquid pre-fibrillized state prior to printing. The liquid stability occurs due to the incorporation of ethylenediaminetetraacetic acid (EDTA) during dialysis of the collagen. Collagen inks were 3D-printed using two different printers. The resulting scaffolds were further processed using two different chemical crosslinkers, 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride)/N-hydroxysuccinimide (EDC/NHS) and genipin; gold nanoparticles were conjugated to the scaffolds. The 3D-printed scaffolds were characterized to determine their extrudability, stability, amount of AuNP conjugated, and overall biocompatibility via cell culture studies using fibroblast cells and stroma cells. The results demonstrated that the liquid collagen ink was amendable to 3D printing and was able to maintain its 3D shape. The scaffolds could be conjugated with gold nanoparticles and demonstrated enhanced biocompatibility. It was concluded that the liquid collagen ink is a good candidate material for the 3D printing of tissue scaffolds. Full article
(This article belongs to the Special Issue Advanced Biomaterials and Biofabrication)
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