Dear Colleagues,

In the fields of diagnostics and drug delivery, nanosized carriers of endogenous and exogenous bioactive molecules are emerging as valuable tools in precision medicine, being considered theranostics, i.e., nanocarriers with therapeutic functionalities, but also vehicles of biomarkers for diagnostic and prognostic application to personalize the therapeutic intervention. Among the proposed tools, natural nanoparticles, i.e., extracellular vesicles, have also been proposed as cargoes for proteins, lipids and oligonucleotides from the parental cell. New perspectives in nanocarrier-assisted therapeutics clinical application derive from cutting-edge, technologically advanced solutions that can overcome limits in the reproducibility and reliability of the proposed protocols. In the case of extracellular vesicles, some of the problems related to partial purification, limited resolution and poor yield are limiting their use. In the field of regenerative medicine and regenerative rehabilitation, nanoparticles and nanocarriers, including extracellular vesicles released by stem cells, have demonstrated their ability to foster recovery and repair of damaged and aged tissues, but application methods and efficacy are debated mainly because of technical challenges.

This Special Issue will focus on recent advances in the field of nanocarrier-assisted therapeutics and extracellular vesicles. Specific areas of interest include—but are not limited to—advanced methodologies for the use of nanocarriers and extracellular vesicles for diagnostic and drug delivery, biosensors and innovative techniques for the detection of EVs as biomarkers for precision medicine, the application of EVs and other nanocarriers in tissue regeneration and regenerative rehabilitation. Particular interest is dedicated to development of new devices, including optical imaging, spectroscopy and spectrometry, coupled with artificial intelligence for the use of nanocarriers as therapeutic and diagnostic tools.

Dr. Alice Gualerzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• theranostics
• nanocarrier-assisted therapeutics
• extracellular vesicles
• nanoparticles
• nanotechnologies
• precision medicine
• regenerative medicine
• sensors