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Micromachines
Special Issues
N/MEMS for Biological Applications: Biosensors and Microfluidics
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N/MEMS for Biological Applications: Biosensors and Microfluidics

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3492

Special Issue Editor

Dr. Jinsik Kim

E-Mail Website
Guest Editor
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Korea
Interests: biosensors; microfluidics; N/MEMS; microTAS; bioelectronics

Special Issue Information

Dear Colleagues,

Nano- and micro-electromechanical systems (N/MEMS) have led the tremendous development of microelectronics such as cell phones, ink-jet printers, or optical communications over the past 2–30 years through the convergence of electrical and mechanical fields. The driving force of the development with N/MEMS has also begun in biological applications, leading to various changes to overcome the limitations and provide new approaches in biological applications. There are many examples, but the most representative changes made by N/MEMS in biological applications are the detection of tiny amounts of protein in the blood using a nano-sized electrical sensor or loading cells on microfluidic chips to immediately detect substances in cells, such as a lab-on-a-chip. The role of N/MEMS in biological applications will continue to grow and produce significant results.

Accordingly, the main goal of present Special Issue is the introduction of showcase research papers, communications, and review articles about the applications of N/MEMS technologies in bio-fields such as electrical miniaturized biosensors, microfluidic chips for cell culturing, or biomimicking devices. More topics related to this Special Issue are described in the keywords below.

We look forward to receiving your submissions!

Dr. Jinsik Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano-biosensors
  • mechanical sensors (cantilever, diaphragm)
  • PCR chips
  • microfluidic chips
  • stretchable sensors
  • electroceuticals
  • microsurgery
  • point-of-care
  • lab-on-a-chip
  • ultrasound transducers
  • N/MEMS in bio-applications

Published Papers (1 paper)

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Research

14 pages, 9518 KiB  
Article
Design of a Hand-Held and Battery-Operated Digital Microfluidic Device Using EWOD for Lab-on-a-Chip Applications
by Nicholas Grant, Brian Geiss, Stuart Field, August Demann and Thomas W. Chen
Micromachines 2021, 12(9), 1065; https://doi.org/10.3390/mi12091065 - 01 Sep 2021
Cited by 11 | Viewed by 2953
Abstract
Microfluidics offer many advantages to Point of Care (POC) devices through lower reagent use and smaller size. Additionally, POC devices offer the unique potential to conduct tests outside of the laboratory. In particular, Electro-wetting on Dielectric (EWOD) microfluidics has been shown to be [...] Read more.
Microfluidics offer many advantages to Point of Care (POC) devices through lower reagent use and smaller size. Additionally, POC devices offer the unique potential to conduct tests outside of the laboratory. In particular, Electro-wetting on Dielectric (EWOD) microfluidics has been shown to be an effective way to move and mix liquids enabling many PoC devices. However, much of the research surrounding these microfluidic systems are focused on a single aspect of the system capability, such as droplet control or a specific new application at the device level using the EWOD technology. Often in these experiments the supporting systems required for operation are bench top equipment such as function generators, power supplies, and personal computers. Although various aspects of how an EWOD device is capable of moving and mixing droplets have been demonstrated at various levels, a complete self-contained and portable lab-on-a-chip system based on the EWOD technology has not been well demonstrated. For instance, EWOD systems tend to use high voltage alternating current (AC) signals to actuate electrodes, but little consideration is given to circuitry size or power consumption of such components to make the entire system portable. This paper demonstrates the feasibility of integrating all supporting hardware and software to correctly operate an EWOD device in a completely self-contained and battery-powered handheld unit. We present results that demonstrate a complete sample preparation flow for deoxyribonucleic acid (DNA) extraction and isolation. The device was designed to be a field deployable, hand-held platform capable of performing many other sample preparation tasks automatically. Liquids are transported using EWOD and controlled via a programmable microprocessor. The programmable nature of the device allows it to be configured for a variety of tests for different applications. Many considerations were given towards power consumption, size, and system complexity which make it ideal for use in a mobile environment. The results presented in this paper show a promising step forward to the portable capability of microfluidic devices based on the EWOD technology. Full article
(This article belongs to the Special Issue N/MEMS for Biological Applications: Biosensors and Microfluidics)
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