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Micromachines
Special Issues
State-of-the-Art Microfluidic Technology in Europe
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State-of-the-Art Microfluidic Technology in Europe

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 7019

Special Issue Editor

Dr. Ville Jokinen

E-Mail Website
Guest Editor
Department of Chemistry and Materials Science, School of Chemical Engineering, Aalto University, Micronova, Tietotie 3, 02150 Espoo, Finland
Interests: micro and nanofabrication; polymer materials; microfluidics for cell biology and analytical chemistry; wetting; superhydrophobicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Microfluidics has made significant progress in its several-decades-long existence as a scientific field. The need for the field has never been more clear than it is today. Microfluidics has the potential to offer solutions in, e.g., medical diagnostics, drug development, and environmental analysis.

This Special Issue invites contributions from the European microfluidics community on their latest advances in the field of microfluidics. For the purposes of this Special Issue, microfluidics is defined broadly to encompass not only traditional fluidic channels but also, e.g., droplet manipulation on surfaces or the use of paper or other porous matrices. The focus of the submissions should be on application of microfluidics or new microfluidic components/principles. Submissions based on new materials and fabrication methods are also invited, but they need to have a clear link to microfluidics as otherwise, they might fall outside the scope of this Special Issue. This Special Issue seeks to showcase research papers, communications, and review articles that focus on microfluidic technology in Europe.

Dr. Ville Jokinen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-chip
  • µTAS
  • droplet microfluidics
  • digital microfluidics
  • paper microfluidics
  • capillary filling
  • organ-on-chip

Published Papers (2 papers)

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Research

12 pages, 4471 KiB  
Article
Acoustic Cell Patterning in Hydrogel for Three-Dimensional Cell Network Formation
by Kyo-in Koo, Andreas Lenshof, Le Thi Huong and Thomas Laurell
Micromachines 2021, 12(1), 3; https://doi.org/10.3390/mi12010003 - 22 Dec 2020
Cited by 17 | Viewed by 2923
Abstract
In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 [...] Read more.
In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was continuously perfused by fibroblast cells suspended in sodium alginate generated a hydrogel string, with the fibroblasts aligned in single or quadruple streams. In the transition from the one-cell stream to the four-cell streams, the aligned fibroblast cells were continuously interconnected in the form of a branch and a junction. The ultrasound-exposed fibroblast cells displayed over 95% viability up to day 10 in culture medium without any significant difference from the unexposed fibroblast cells. This acoustofluidic method will be further applied to create a vascularized network by replacing fibroblast cells with human umbilical vein endothelial cells. Full article
(This article belongs to the Special Issue State-of-the-Art Microfluidic Technology in Europe)
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14 pages, 3679 KiB  
Article
A Microfluidic Chip Architecture Enabling a Hypoxic Microenvironment and Nitric Oxide Delivery in Cell Culture
by Samineh Barmaki, Daniela Obermaier, Esko Kankuri, Jyrki Vuola, Sami Franssila and Ville Jokinen
Micromachines 2020, 11(11), 979; https://doi.org/10.3390/mi11110979 - 30 Oct 2020
Cited by 8 | Viewed by 3719
Abstract
A hypoxic (low oxygen level) microenvironment and nitric oxide paracrine signaling play important roles in the control of both biological and pathological cell responses. In this study, we present a microfluidic chip architecture for nitric oxide delivery under a hypoxic microenvironment in human [...] Read more.
A hypoxic (low oxygen level) microenvironment and nitric oxide paracrine signaling play important roles in the control of both biological and pathological cell responses. In this study, we present a microfluidic chip architecture for nitric oxide delivery under a hypoxic microenvironment in human embryonic kidney cells (HEK-293). The chip utilizes two separate, but interdigitated microfluidic channels. The hypoxic microenvironment was created by sodium sulfite as the oxygen scavenger in one of the channels. The nitric oxide microenvironment was created by sodium nitroprusside as the light-activated nitric oxide donor in the other channel. The solutions are separated from the cell culture by a 30 µm thick gas-permeable, but liquid-impermeable polydimethylsiloxane membrane. We show that the architecture is preliminarily feasible to define the gaseous microenvironment of a cell culture in the 100 µm and 1 mm length scales. Full article
(This article belongs to the Special Issue State-of-the-Art Microfluidic Technology in Europe)
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