Special Issue "Micro/Nano Devices in Biological Medicine"

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: 10 March 2020.

Special Issue Editor

Prof. Satoshi Uchida
E-Mail Website
Guest Editor
1. Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan
2. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan
Interests: gene therapy; messenger RNA therapeutics; polymeric micelle; drug delivery system; biomaterial; RNA nanotechnology

Special Issue Information

Dear Colleagues,

Various medical devices have been developed, especially in the past hundred years, e.g., artificial heart–lung machine, and computed tomography, which tremendously improved the quality of medical care. In recent decades, researchers have started to focus on the development of devices that function at nano- or micro-scales for advanced therapy and diagnosis. Some of the devices are based on technologies such as microfluidics and biosensors, and intend to work outside patients’ body for diagnosis, while vigorous efforts are being devoted to making such diagnostic devices wearable or implantable. Other devices assist the functioning of therapeutic and diagnostic agents inside patients’ bodies. For example, drug delivery systems allow specific targeting and the control of the functioning of these agents in specific organs, cells, and organelles, by using nano- or micro-particles or microneedles, to maximize their effects and minimize adverse outcomes. Nucleotide-based therapeutics, including DNA, messenger RNA, small interference RNA, and anti-sense oligonucleotide, often require nano- or micro-devices to prevent their degradation before reaching target sites and facilitate their functioning inside cells. This Special Issue welcomes your contribution in these fields at various stages, from the basic technological development of device components to the biomedical application of the devices, in the form of communications, original articles, and reviews.

Prof. Satoshi Uchida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • Biosensors
  • Drug delivery systems
  • Non-viral gene delivery
  • Nucleotide therapeutics
  • Biomaterials
  • Microneedle
  • Controlled release

Published Papers (1 paper)

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Research

Open AccessArticle
Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability
Micromachines 2019, 10(11), 755; https://doi.org/10.3390/mi10110755 - 06 Nov 2019
Abstract
Microencapsulation of islets can protect against immune reactions from the host immune system after transplantation. However, sufficient numbers of islets cannot be transplanted due to the increase of the size and total volume. Therefore, thin and stable polymer membranes are required for the [...] Read more.
Microencapsulation of islets can protect against immune reactions from the host immune system after transplantation. However, sufficient numbers of islets cannot be transplanted due to the increase of the size and total volume. Therefore, thin and stable polymer membranes are required for the microencapsulation. Here, we undertook the cell microencapsulation using poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) and layer-by-layer membrane of multiple-arm PEG. In order to examine the membrane stability, we used different molecular weights of 4-arm PEG (10k, 20k and 40k)-Mal to examine the influence on the polymer membrane stability. We found that the polymer membrane made of 4-arm PEG(40k)-Mal showed the highest stability on the cell surface. Also, the polymer membrane did not disturb the insulin secretion from beta cells. Full article
(This article belongs to the Special Issue Micro/Nano Devices in Biological Medicine)
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