Rapid Prototyping in Biomedical Engineering: Design, Fabrication, and Evaluation

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 502

Special Issue Editor

1. Department of Physics, Coe College, Cedar Rapids, IA 52402, USA
2. Department of Engineering Physics, Coe College, Cedar Rapids, IA 52402, USA
Interests: microfabrication; tissue engineering; human disease modeling; drug discovery

Special Issue Information

Dear Colleagues,

There is a unique splendor in the beginning of an academic research project: it is curiosity-driven and full of potential. Every scientific journey begins by standing on the shoulders of giants; through this, progress is made, lessons are learned, and we move one step closer to understanding and curing a disease.

This Special Issue seeks contributions that detail the authentic lifecycle of biomedical engineering (BME) prototyping, from initial design to process optimization and validation. We welcome submissions from all researchers, especially junior researchers and students who have just started their research project in BME, including the following topics:

  • Microfluidic solution for tissue chips and drug discovery;
  • The design, fabrication, and validation of biomedical microdevices for disease modeling, biosensing, or diagnostics (in vitro or in vivo);
  • Experimental methods or engineering approaches that reduce the major barriers between basic research discoveries and clinical trials.

Editorial Scope and Focus: To distinguish this Special Issue and promote methodological rigor, we will prioritize original research articles that demonstrate high transparency and reproducibility:

  • Focused Context: Authors are encouraged to present concise introductions that trace the direct iteration of the innovation, avoiding broad historical reviews in favor of specific technical contexts.
  • Replicable Methods: Methodologies must be described with sufficient detail to ensure independent reproducibility, placing a high value on technical completeness.
  • Rigorous Evaluation and Failure Analysis: We explicitly welcome studies that define the boundaries of experimental techniques. These include rigorous "failure mode analysis" and the reporting of null results, provided that they offer a significant understanding of the limits and constraints of the methodology.
  • Primary Research Only: To maintain a focus on experimental validation and data, review articles will not be considered for this specific Special Issue.

Dr. Xiang Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical rapid prototyping
  • microfabrication
  • biofabrication
  • methodological reproducibility
  • process validation
  • failure analysis
  • design optimization

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 6380 KB  
Article
Towards a Nitinol-Based Microfabricated Approach to Repair Long-Gap Esophageal Atresia
by Ana R. Domingues, Joana Silva, Lara Teles, Bernardo S. Dores, Alice Miranda, Sofia Martinho, Jorge Correia-Pinto, Bruno Esteves, Eliana M. F. Vieira, Manuel F. Silva, José H. Correia and Sara Pimenta
Micromachines 2026, 17(5), 582; https://doi.org/10.3390/mi17050582 - 7 May 2026
Viewed by 269
Abstract
Long-gap esophageal atresia is a congenital anomaly that requires challenging repair procedures that are often associated with complications. This work proposes the use of nitinol to repair long-gap esophageal atresia. A first proof-of-concept with commercial nitinol is presented. Experimental tests and simulations were [...] Read more.
Long-gap esophageal atresia is a congenital anomaly that requires challenging repair procedures that are often associated with complications. This work proposes the use of nitinol to repair long-gap esophageal atresia. A first proof-of-concept with commercial nitinol is presented. Experimental tests and simulations were performed, including the application of electrical currents to promote nitinol heating and consequent contraction, tensile tests, chemical analysis, and ex vivo tests using porcine esophageal tissues. A preliminary experiment is also presented regarding NiTi sputtering deposition and the morphological, chemical, and crystallographic analysis of the thin-films, featuring the implementation of a microfabricated solution. The experimental electrical tests were in accordance with the simulations. The nitinol electrical resistance (0.8–1.5 Ω) decreased as its temperature increased (20–60 °C) with the application of electrical current (<1 A), which was consistent with the experimental Seebeck coefficient (6.49 ± 0.46 µV/K). The measured forces (6.5 N at 45 °C) are also in accordance with traction sutures. Chemical analysis revealed a passive titanium dioxide layer reported for nitinol. Regarding the ex vivo tests, the average nitinol final length was 28.5 mm, below 30 mm (threshold for long-gap esophageal atresia). Finally, preliminary results from NiTi sputtering confirmed well-controlled deposition and the viability of scaling this approach, opening new avenues for nitinol-based biomedical devices. Full article
Show Figures

Figure 1

Back to TopTop