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Micromachines
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Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition
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Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B2: Biofabrication and Tissue Engineering".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 6072

Special Issue Editor

Dr. Liqun Ning

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Cleveland State University, Cleveland, OH 44115, USA
Interests: advanced manufacturing; biomaterials; biomechanics; regenerative medicine; disease modelling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advanced biomanufacturing, along with biomaterials and cell/stem cell technology, has shown great promise for engineering highly tunable tissue analogues to address significant challenges in biomedical engineering. This Special Issue aims to collect high-quality original and review articles on the development/creation of cutting-edge engineering technologies, artificial constructs, and devices for broad applications in biomedical engineering and to explore the most important questions in the field. The topics include, but are not limited to, advanced biomanufacturing, 3D printing and bioprinting, biomaterials and bioinks, biomanufactured constructs/devices for regenerative medicine, disease modeling, and drug screening, as well as advanced imaging methods/technologies to non-invasively track biomanufactured structures in living animal models and/or human patients.

Dr. Liqun Ning
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced biomanufacturing
  • biomaterials
  • cell/stem cell
  • regenerative medicine
  • disease modeling
  • drug screening
  • advanced imaging

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (3 papers)

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Research

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15 pages, 66581 KiB  
Article
The Impact of Titanium Hydroxyapatite Doping on the Mechanical and Biological Properties of Photocured Resin
by Xiaopan Li, Chao Yao, Junfu Shen, Siqi Zhu, Yiyun Kong, Chun Yao, Yuankai Zhou and Jing Xia
Micromachines 2024, 15(8), 1040; https://doi.org/10.3390/mi15081040 - 16 Aug 2024
Cited by 2 | Viewed by 1742
Abstract
Photocured resin materials are widely used in various fields, such as 3D printing, medical applications, and dentistry. However, the strength, wear resistance, and antibacterial properties of photocured resin are relatively limited, rendering it susceptible to potential failures. In this recent study, photocured composite [...] Read more.
Photocured resin materials are widely used in various fields, such as 3D printing, medical applications, and dentistry. However, the strength, wear resistance, and antibacterial properties of photocured resin are relatively limited, rendering it susceptible to potential failures. In this recent study, photocured composite resins incorporating titanium-doped hydroxyapatite (Ti-HAp) were fabricated to investigate their mechanical and biological properties. It was found that the hardness and wear resistance increased with the addition of an appropriate amount of hydroxyapatite (HAp). Specifically, the 6wt%HAp resin demonstrated superior hardness. Compared with the 6wt%HAp resin, the acid resistance and wear resistance improved when an appropriate amount of Ti-HAp was added. Notably, the resin containing 0.56%Ti-HAp demonstrated superior wear resistance. Additionally, the antibacterial performance improved with higher titanium (Ti) content, showcasing a 71.9% improvement in the resin containing 1.37%Ti-HAp compared with the 6wt%HAp resin, alongside commendable remineralization capabilities. In summary, the Ti-HAp composite resin showed enhanced mechanical and biological properties, meeting clinical standards in terms of mechanical and antibacterial properties. Full article
(This article belongs to the Special Issue Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition)
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19 pages, 2441 KiB  
Article
A Simulation of the Mechanical Testing of the Cell Membrane and Cytoskeleton
by Yue Du, Dai Cheng, Zhanli Yang, Yaowei Liu, Qili Zhao, Mingzhu Sun, Haifeng Li and Xin Zhao
Micromachines 2024, 15(4), 431; https://doi.org/10.3390/mi15040431 - 23 Mar 2024
Cited by 1 | Viewed by 1608
Abstract
Cell models play a crucial role in analyzing the mechanical response of cells and quantifying cellular damage incurred during micromanipulation. While traditional models can capture the overall mechanical behavior of cells, they often lack the ability to discern among distinct cellular components. Consequently, [...] Read more.
Cell models play a crucial role in analyzing the mechanical response of cells and quantifying cellular damage incurred during micromanipulation. While traditional models can capture the overall mechanical behavior of cells, they often lack the ability to discern among distinct cellular components. Consequently, by employing dissipative particle dynamics, this study constructed a triangular network-like representation of the cell membrane along with cross-linked cytoskeletal chains. The mechanical properties of both the membrane and cytoskeleton were then analyzed through a series of simulated mechanical tests, validated against real-world experiments. The investigation utilized particle-tracking rheology to monitor changes in the mean square displacements of membrane particles over time, facilitating the analysis of the membrane’s storage and loss moduli. Additionally, the cytoskeletal network’s storage and loss moduli were examined via a double-plate oscillatory shear experiment. The simulation results revealed that both the membrane and cytoskeleton exhibit viscoelastic behavior, as evidenced by the power-law dependency of their storage and loss moduli on frequency. Furthermore, indentation and microinjection simulations were conducted to examine the overall mechanical properties of cells. In the indentation experiments, an increase in the shear modulus of the membrane’s WLCs correlated with a higher Young’s modulus for the entire cell. Regarding the microinjection experiment, augmenting the microinjection speed resulted in reduced deformation of the cell at the point of membrane rupture and a lower percentage of high strain. Full article
(This article belongs to the Special Issue Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition)
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Review

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32 pages, 6422 KiB  
Review
Research Advances in Electrospun Nanofiber Membranes for Non-Invasive Medical Applications
by Junhua Wang, Chongyang You, Yanwei Xu, Tancheng Xie and Yi Wang
Micromachines 2024, 15(10), 1226; https://doi.org/10.3390/mi15101226 - 30 Sep 2024
Cited by 12 | Viewed by 2089
Abstract
Non-invasive medical nanofiber technology, characterized by its high specific surface area, biocompatibility, and porosity, holds significant potential in various medical domains, including tissue repair and biosensing. It is increasingly becoming central to healthcare by offering safer and more efficient treatment options for contemporary [...] Read more.
Non-invasive medical nanofiber technology, characterized by its high specific surface area, biocompatibility, and porosity, holds significant potential in various medical domains, including tissue repair and biosensing. It is increasingly becoming central to healthcare by offering safer and more efficient treatment options for contemporary medicine. Numerous studies have explored non-invasive medical nanofibers in recent years, yet a comprehensive overview of the field remains lacking. In this paper, we provide a comprehensive summary of the applications of electrospun nanofibers in non-invasive medical fields, considering multiple aspects and perspectives. Initially, we introduce electrospinning nanofibers. Subsequently, we detail their applications in non-invasive health, including health monitoring, personal protection, thermal regulation, and wound care, highlighting their critical role in improving human health. Lastly, this paper discusses the current challenges associated with electrospun nanofibers and offers insights into potential future development trajectories. Full article
(This article belongs to the Special Issue Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition)
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