Optofluidic Devices and Their Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 1 January 2026 | Viewed by 223

Special Issue Editor


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Guest Editor
Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra Precision Optical Manufacturing, Fudan University, Shanghai 200433, China
Interests: biomedical photonics; integrated optics

Special Issue Information

Dear Colleagues,

Optofluidics is a rapidly advancing field combining optics and microfluidics, enabling the precise control of light and fluids at micro- and nanoscale levels. This integration has catalyzed innovations across various domains, particularly in biomedical diagnostics, environmental sensing, and energy harvesting. Optofluidic lab-on-a-chip devices, for instance, allow rapid, sensitive, and portable analysis of biological samples, revolutionizing diagnostics by facilitating on-site testing and real-time monitoring of biomarkers and pathogens. Furthermore, optofluidic sensors can detect environmental pollutants with exceptional sensitivity, enabling prompt detection of contaminants in water and air.

In the energy sector, optofluidics contributes to the development of solar concentrators and artificial photosynthesis systems, improving light harvesting and enhancing renewable energy technologies. Additionally, optofluidic microscopy and spectroscopy offer compact, high-resolution imaging and analysis tools, expanding accessibility to remote settings. The fabrication of these devices has evolved with advanced techniques such as 3D printing, enhancing precision and scalability.

While promising, challenges such as integration complexity, manufacturing cost, and durability remain. Continued research is anticipated to drive the field forward, with potential impacts on personalized medicine, environmental monitoring, and sustainable energy solutions. This Special Issue explores recent breakthroughs, application advancements, and future directions in the field of optofluidics.

Prof. Dr. Xiang Wu
Guest Editor

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Keywords

  • optofluidics
  • lab-on-a-chip
  • microfluidics
  • biomedical diagnostics
  • environmental sensing
  • solar energy harvesting
  • artificial photosynthesis
  • optofluidic microscopy
  • spectroscopy
  • pollutant detection
  • single-cell analysis
  • portable imaging
  • 3D printing in optofluidics
  • hybrid integration
  • personalized medicine
  • molecular analysis
  • renewable energy solutions
  • device fabrication techniques
  • miniaturized analytical systems
  • high-sensitivity detection
  • biosensors

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Published Papers (1 paper)

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Research

17 pages, 3651 KB  
Article
Optofluidic Lens Refractometer
by Yifan Zhang, Qi Wang, Yuxiang Li, Junjie Liu, Ziyue Lin, Mingkai Fan, Yichi Zhang and Xiang Wu
Micromachines 2025, 16(10), 1160; https://doi.org/10.3390/mi16101160 - 13 Oct 2025
Abstract
In the face of increasingly severe global environmental challenges, the development of low-cost, high-precision, and easily integrable environmental monitoring sensors is of paramount importance. Existing optical refractive index sensors are often limited in application due to their complex structures and high costs, or [...] Read more.
In the face of increasingly severe global environmental challenges, the development of low-cost, high-precision, and easily integrable environmental monitoring sensors is of paramount importance. Existing optical refractive index sensors are often limited in application due to their complex structures and high costs, or their bulky size and difficulty in automation. This paper proposes a novel optical microfluidic refractometer, consisting solely of a laser source, an optical microfluidic lens, and a CCD detector. Through an innovative “simple structure + algorithm” design, the sensor achieves high-precision measurement while significantly reducing cost and size and enhancing robustness. With the aid of signal processing algorithms, the device currently enables the detection of refractive index gradients as low as 1.4 × 10−5 within a refractive index range of 1.33 to 1.48. Full article
(This article belongs to the Special Issue Optofluidic Devices and Their Applications)
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