Responsive Polymeric Nanomaterials and Hydrogels: Synthesis, Characterization, and Applications

A special issue of Micro (ISSN 2673-8023). This special issue belongs to the section "Microscale Materials Science".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1102

Special Issue Editor


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Guest Editor
1. Department of Bioengineering, U.A. Whitaker College of Engineering, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA
2. Department of Chemistry, Faculty of Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey
Interests: natural polymers; glycosaminoglycans; sugar alcohols; carbohydrates; polyphenolics; amino acids; peptides; nano/microparticles; antioxidant; anti-inflammatory; antimicrobial activity; ROS-scavenging effect; antiviral; antifungal; biocidal; anticancer; controlled release; drug delivery; biocompatible; blood compatible; surface; (bio)interfaces; smart surfaces; surface modification; superhydrophobic; super hydrophilic; (bio)sensor; theragnostic, biopolymeric MRI agents; injectables biopolymeric materials; hydrogel; cryogel; microgel; nanogels; super porous materials; pharmacology; wound healing; wound dressing; medical device; tissue engineering; stimuli-responsive structures; wearables; artificial skin; shape memory polymers; injectable materials; biodegradable active agent carriers; carbon particle; quantum dots, carbon dots, graphene dots, g-C3N4; lubricant, intra-articular and joints injection materials; cosmetics
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Special Issue Information

Dear Colleagues, 

Responsive polymeric nanomaterials are intriguing classes of natural and synthetic molecules, or monomer-derived materials that not only respond to external stimuli but also process the signals and execute the necessary activities accordingly. Responsive materials can be tailored by psychical or chemical crosslinking to generate new nanoscale porous structures, including porous organic polymers, conducting polymers, and hydrogels with varying degrees of crystallinity and amorphous structures. Responsive polymeric nanomaterials can be combined with other natural and synthetic organic and inorganic materials including metals, piezoelectric materials, clays, carbon-based structures (e.g., graphene, carbon quantum dots, and g-C3N4) and so on. These combinations improve and enhance their natural functions, resulting in versatile composites with multi-functional and multi-responsive behaviors. These materials and their respective composites possess additional characteristics that broaden their range of applications.

Responsive polymeric nanomaterials and hydrogels can be prepared in different shapes, sizes, morphologies, and formulations including nanoparticles, nanofibers, nanorods, interpenetrating polymer networks, and nanogels. In addition to responding to environmental stimuli such as pH, temperature, and light, these materials may exhibit self-healing, shape memory, actuation, sound and electromagnetic radiation responsiveness, and smart sensory applications.

This Special Issue focuses on the synthesis and characterization of responsive polymeric nanomaterials, hydrogels, and their composites. These materials have a wide range of applications, including health-related fields such as tissue engineering, artificial organs, and therapeutics, as well as in energy, environment, separation, devices, food, and agriculture.

Dr. Nurettin Sahiner
Guest Editor

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Keywords

  • responsive polymers
  • nanomaterials
  • porous network
  • physical/chemical crosslinking
  • smart materials
  • hydrogels
  • composites

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Published Papers (2 papers)

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Review

22 pages, 1988 KB  
Review
Nanotechnology in Wound Healing: A New Frontier in Regenerative Medicine
by Alibala Aliyev, Aygun Israyilova, Ulviyya Hasanova, Zarema Gakhramanova and Aida Ahmadova
Micro 2025, 5(4), 60; https://doi.org/10.3390/micro5040060 - 10 Dec 2025
Abstract
The process of wound healing is intricate and regulated by a network of cellular, molecular, and biochemical pathways. Acute wounds progress via distinct phases of hemostasis, inflammation, proliferation, and remodeling. Chronic wounds frequently cease to heal and exhibit resistance to conventional therapies. These [...] Read more.
The process of wound healing is intricate and regulated by a network of cellular, molecular, and biochemical pathways. Acute wounds progress via distinct phases of hemostasis, inflammation, proliferation, and remodeling. Chronic wounds frequently cease to heal and exhibit resistance to conventional therapies. These types of injuries are frequently attributed to diabetes, infection, or senescence. Existing therapies are constrained due to their ineffectiveness against bacteria, inability to promote regeneration, and inadequate control over medication release. Nanotechnology presents novel methods to overcome these challenges by providing multifunctional platforms that enable biological repair and medicinal delivery. Nanoparticles, which combat germs and modulate the immune system, in addition to being intelligent carriers that react to pH, oxidative stress, or enzymatic activity, provide targeted and adaptive wound therapy. Nanocomposite hydrogels are particularly advantageous as biointeractive dressings due to their ability to maintain wound moisture while facilitating regulated drug delivery. Recent advancements indicate their potential to aid in tissue regeneration, enhance therapy precision, and address issues related to safety and translation. Nanotechnology-based approaches, especially smart hydrogels, give significant promise to transform the future of wound care due to their flexibility, adaptability, and efficiency. Full article
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25 pages, 6312 KB  
Review
Early Insights into AI and Machine Learning Applications in Hydrogel Microneedles: A Short Review
by Jannah Urifa and Kwok Wei Shah
Micro 2025, 5(4), 48; https://doi.org/10.3390/micro5040048 - 31 Oct 2025
Viewed by 842
Abstract
Hydrogel microneedles (HMNs) act as non-invasive devices that can effortlessly merge with the human body for drug delivery and diagnostic purposes. Nonetheless, their improvement is limited by intricate and repetitive issues related to material composition, structural geometry, manufacturing accuracy, and performance enhancement. At [...] Read more.
Hydrogel microneedles (HMNs) act as non-invasive devices that can effortlessly merge with the human body for drug delivery and diagnostic purposes. Nonetheless, their improvement is limited by intricate and repetitive issues related to material composition, structural geometry, manufacturing accuracy, and performance enhancement. At present, there are only a limited number of studies accessible since artificial intelligence and machine learning (AI/ML) for HMN are just starting to emerge and are in the initial phase. Data is distributed across separate research efforts, spanning different fields. This review aims to tackle the disjointed and narrowly concentrated aspects of current research on AI/ML applications in HMN technologies by offering a cohesive, comprehensive synthesis of interdisciplinary insights, categorized into five thematic areas: (1) material and microneedle design, (2) diagnostics and therapy, (3) drug delivery, (4) drug development, and (5) health and agricultural sensing. For each domain, we detail typical AI methods, integration approaches, proven advantages, and ongoing difficulties. We suggest a systematic five-stage developmental pathway covering material discovery, structural design, manufacturing, biomedical performance, and advanced AI integration, intended to expedite the transition of HMNs from research ideas to clinically and commercially practical systems. The findings of this review indicate that AI/ML can significantly enhance HMN development by addressing design and fabrication constraints via predictive modeling, adaptive control, and process optimization. By synchronizing these abilities with clinical and commercial translation requirements, AI/ML can act as key facilitators in converting HMNs from research ideas into scalable, practical biomedical solutions. Full article
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