Insulin Resistance in the 2020's

Dear Colleagues,

Insulin resistance (IR) is defined as the impaired intracellular signaling of endogenous and exogenous insulin. IR is a major key player in those metabolic derangements that characterize physiological states (e.g., puberty and pregnancy) and pathological conditions (e.g., diabesity and metabolic syndrome). In particular, IR is a key determinant of a wide-ranging spectrum of diseases spanning cardio-nephro-metabolic disorders to the end-stage failure of such vital organs as the heart, the kidney and the liver, and also certain types of cancer such as, for example, gastrointestinal and breast cancers.

The obesogenic world in which a large part of the human population resides is a recognized facilitator of IR development and progression. However, genetic traits may predispose to the specific array of complications and manifestations that typically characterize patients. Therefore, owing to its epidemiological and clinical burden, IR is an attractive topic both in basic and clinical research. Interest in molecular mechanisms, translational approaches and strong interdisciplinarity characterize IR research, which brings together investigator-driven studies as well as industry-sponsored investigations.

The aim of this Topic Collection is to publish high-quality review and research papers in IR. We make a call for well-written review articles and original papers spanning the areas of glucose metabolism, lipid metabolism, obesity, cardiovascular and fatty liver disease. The scope of this Topic Collection includes, but is not limited to: homeostatic model assessment, insulin sensitivity, Type 2 diabetes, polycystic ovary syndrome, nonalcoholic fatty liver disease, oxidative stress, inflammation, beta cell function and hepatic steatosis.

Dr. Amedeo Lonardo
Guest Editor

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