Honorary Special Issue Dedicated to Prof. Giovanni Targher–the Metabolic Fatty Liver Syndromes: MASLD/MAFLD/NAFLD

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 216

Special Issue Editors

Special Issue Information

Dear Colleagues,

This year marks the 21st anniversary of the publications of Professor Giovanni Targher (ORCID 0000-0002-4325-3900), a world-leading researcher on the role of metabolic fatty liver syndromes including MASLD/MAFLD/NAFLD in the development of extra-hepatic complications, especially nephro-cardiovascular diseases, and cancer. MASLD/MAFLD/NAFLD, collectively labelled metabolic fatty liver syndromes (MFLS), describe the spectrum of steatosis closely associated with metabolic dysfunction. They are currently the most common chronic liver diseases globally and a leading cause of cirrhosis and hepatocellular carcinoma.

With an H index of 99, Professor Targher is one of the most brilliant clinical Italian researchers. As a diabetologist with a solid background in general endocrinology and internal medicine, he has approached the MFLS arena from diabetes’ point of view, rapidly gaining insight into this very common liver disease as a systemic disorder. His scientific career, which flourished based on outstanding scientific intuitions and an exceptional attitude towards developing large amounts of work within highly intensive time schedules, includes numerous collaborations outside of Italy, a testament to Professor Targher’s international academic prestige and his frank, gentle, and friendly personality.

His research has shown that NAFLD, especially in its advanced forms, is a risk factor for the development and progression of cardiac alterations in patients with and without diabetes, often leading to their death. His papers have inspired many other scientists to explore the independent role of NAFLD in the development of cardiovascular disease, identifying it as a major clinical and public health issue globally.

As a leading figure in epidemiological sciences and in clinically relevant meta-analytic techniques, Professor Targher has also conducted high-standard investigations in the NAFLD arena regarding insulin resistance, vitamin D, genetics, ceramides, uric acid, adiponectin, PCSK9, N-terminal propeptide of type III procollagen, and SARS-CoV-2 infection. His studies have also expanded our understanding of secondary NAFLD forms, including those associated with dysthyroidism. His participation in guidelines and consensus conferences placed him at the forefront of the change in nomenclature from NAFLD to metabolic (dysfunction)-associated fatty liver disease (MAFLD) and, ultimately, metabolic dysfunction-associated steatotic liver disease (MASLD).

In his honor, this Special Issue focuses on the role of the MFLS (MASLD/MAFLD/NAFLD) in the development of various extra-hepatic complications, such as cardiovascular disease, chronic kidney disease, diabetes mellitus, and cancer.

As both his colleagues and friends, we are honored to guest edit the introduction for the present Special Issue, which we hope will be a great success.

You may choose our Joint Special Issue in Biomolecules.

Dr. Alessandro Mantovani
Dr. Amedeo Lonardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nonalcoholic fatty liver disease (NAFLD)
  • metabolic associated fatty liver disease (MAFLD)
  • nonalcoholic steatohepatitis (NASH)
  • metabolic dysfunction-associated steatotic liver disease (MASLD)
  • fatty liver

Published Papers

This special issue is now open for submission.
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