Special Issue "Application of Metabolomics in Characterization of Novel Bioactive Natural Products"
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 9995
Interests: ultra-high resolution tools; non-targeted metabolomics; bioactives; natural products; cell painting; data science
Living organisms produce bioactive molecules for defense or adaption to their environment; so-called natural products. These have been used for millennia, for example, as flavors and dyes, or in traditional medicine. Despite the large number of natural products already known, unexplored biodiversity is far from being exhausted, due to various reasons such as difficult screening, identification, and complex synthesis or extraction in low yields. Currently, the paradigm of natural product discovery needs to be re-examined considering the technological progress that has been made. Metabolomics combined with sophisticated data mining and advanced activity assays can greatly accelerate bioactivity screenings, guide chemical analysis, and improve de-replication. Moreover, metabolites are themselves biochemical interactors. They often modify multiple targets and lead to complex changes of metabolic networks. In many diseases, intertwined metabolic networks are found and lead to multi-layered pathophysiology. Natural products and their complex extracts act on multiple targets and offer the opportunity to study and modify such network effects.
Dr. Constanze Müller
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- hit discovery
- data integration/-science
- traditional medicines
- poly-pharmaceutical networks
- phenotypic screenings
- (non-)targeted assays
- single cell
- metabolic modeling
- bioinformatics-guided identification