Metabolic Networks

Dear Colleagues,

Thanks to last year’s technological and methodological developments, metabolomics now allows us to detect and identify tens to hundreds of metabolites constituting metabolic fingerprints of environmental or genetic stresses. These metabolic profiles provide highly valuable information on the physiological status of cells, tissues or organisms. The current challenge lies in putting back these lists of metabolites in the context of genome scale metabolic networks. In fact, metabolic networks aim at gathering all the metabolic reactions which can occur in a given organism, hence allowing us to decipher the cascade of reactions connecting metabolites identified in metabolomics.

This Special Issue is devoted to reviewing the current practical aspects of metabolomic data analysis in the context of metabolic networks, starting from network reconstruction, metabolite mapping (with a special challenge in identifier mappings), then discussing state-of-the-art and new network computational analysis methods (graphs, constraint-based modelling) and emphasising the need for new visualisation paradigms to deal with these large networks. We also invite reviews and viewpoints which could help in filling the gap between network modelling and metabolomics data analysis. Finally, we also invite manuscripts showing the use of metabolic networks in the challenging task of metabolite identification.

Dr. Fabien Jourdan
Guest Editor

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