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Special Issue "Metabolomics in Drug Discovery and Development"
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 4249
Special Issue Editor
Interests: development of hyphenated techniques in chromatography and their application to problems in drug metabolism; toxicology and metabonomics
Special Issue Information
Metabolomics/metabonomics is now well established as an essential part of the discovery toolbox for understanding complex biochemical processes, as evidenced by the ever-growing number of applications of metabolomics.
One area of application includes the study of xenobiotics, especially drugs, and their effects on endogenous processes as a means of understanding pharmacology and toxicology. This has led to the development of the burgeoning new field of phamacometabonomics/metabolomics, whilst the exploration of toxicity (toxicometabonomics /metabolomics) dates back to the early days of modern metabolic phenotyping. In addition to looking for their effects on the biological system to which they have been applied, the methodologies used for metabolic phenotyping can also be used to search for the drug/xenobiotic metabolites themselves, and there are a number of examples of this type of application. This Special Issue is devoted to compiling the latest research, current practices, and perspectives for using metabolomics holistically for the investigation of drugs. It is therefore not limited to elucidating the effects of drugs on organisms and cell cultures etc., but also includes its application for tracing a drug and its metabolites, from entry into the body to excretion. We also wish to examine applications that investigate the re-emerging role of the gut microbiota in these processes.
We therefore invite primary research articles on the topics of using metabolomics to perform a detailed characterization of drug effects on endogenous metabolism (in biofluids or tissues), the detection of drug metabolites using metabolomic approaches, and explorations of the effect of drugs on the gut microbiota, and of those microorganisms on the drugs themselves.
The Special Issue is open for submissions now. An extension to the submission deadline may be granted if requested in advance. Accepted papers will be published continuously in the journal (as soon as accepted), and will be listed together on the Special Issue website.
Prof. Dr. Ian D Wilson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug metabolism
- molecular networking