New Biomarkers for Diagnostics in Metabolic Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 13617
Special Issue Editors
Interests: cardiovascular diseases; metabolic diseases; diabetes mellitus; antioxidants
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular disease; atherosclerosis; arterial thrombosis; venous thrombosis; anticoagulants; hereditary thrombophilia; inflammation
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular diseases; hypercoagulability; acute cardiac care; noninvasive cardiovascular imaging techniques
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic processes are the essence of life. Thousands of chemical reactions occur in our bodies every second, forming an intricate web of biological processes that keep us alive and healthy.
However, disaster can strike anytime and anywhere. Acquired or congenital abnormalities of substrates or enzymes can affect one or more pathways of metabolic chains at one or more levels, ultimately ending in disease. The genetic substrate is particularly important whether inherited or de novo mutations are involved, as up to now over a thousand metabolic disorders with a genetic background have been identified. The absence or abnormality of an enzyme or its cofactor or a modulator of a metabolic pathway can lead to either the accumulation or deficiency of a particular metabolite. The clinical impact can range from the complete absence of signs and symptoms, to rapid and severe, and sometimes catastrophic, manifestations ending in early death. Considering that several distinct genetic anomalies can be clinically expressed similarly and that some clinical manifestations have a polygenic origin, the diagnostic approach can be tough if we do not have biomarkers available to help us identify the impaired link in the metabolic chain.
Acquired metabolic diseases are just as numerous and diverse. Under the pressure of external stress factors, the expression of genes and/or the activity of proteins can be affected, which leads to the impairment of metabolisms, and finally, to diseases. From metabolic syndrome to vitamin deficiencies, and from serum electrolyte disorders to exogenous intoxication, there is a wide variety of substrate alterations that can lead to organ or system dysfunction. Once again, biomarkers are vital for diagnosis, for monitoring the response to treatment and possibly for establishing a prognosis.
We invite you to share your experience regarding the newest, specific and useful biomarkers for metabolic diseases. Both original articles and reviews are welcome. Our goal is to provide practitioners with a strong reference point for their diagnostic approach in difficult cases of medical practice, and to provide researchers with solid arguments to guide and channel their effort towards insufficiently explored or understood biomarkers.
Dr. Manuela Ciocoiu
Dr. Minerva Codruta Badescu
Dr. Iris Bararu-Bojan
Guest Editors
Manuscript Submission Information
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Keywords
- acquired metabolic diseases
- hereditary metabolic diseases
- biomarkers
- inflammation
- diabetes mellitus
- dyslipidemia
- storage disease
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