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Metabolites
Special Issues
Polyphenols and Metabolic Diseases
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Polyphenols and Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (30 August 2023) | Viewed by 2942

Special Issue Editors

Dr. Meng Shi

E-Mail Website
Guest Editor
College of Food Science and Technology, Hunan Agricultural University, Changsha, China
Interests: polyphenols; encapsulation; bioavailability; chronic diseases; precision nutrition
Prof. Dr. Si Qin

E-Mail Website
Guest Editor
College of Food Science and Technology, Hunan Agricultural University, Changsha, China
Interests: food precision nutrition; bioactive compounds, AI

Special Issue Information

Dear Colleagues,

In the coming decades, metabolic diseases (MetDs) will represent a significant burden across the world. Redox imbalance, along with chronic inflammatory conditions, can lead to the development of MetDs. Metabolic signaling pathways, especially those involved in glucose, lipid and gut microbiota modulation, are highly associated with MetDs including cancer, cardiovascular diseases, diabetes, obesity, arthrolithiasis, etc. The regular consumption of dietary polyphenols may be associated with a lower incidence of MetDs. Although the basic and molecular mechanisms underpinning the role of polyphenols in MetDs are now more understood, the exact mechanisms and crosslinks remain unknown.

This Special Issue is devoted to multi-omics technologies in nutrition and health, covering topics such as polyphenols’ interaction with one or more components and their incorporation in foods, and the effects of these on MetDs; regulation of polyphenols in MetDs via multi-omics analysis using in vitro or in vivo models; mechanisms of cell redox balance and inflammatory signaling pathways; modulations of intestinal epithelia, gut microbiota, gut–liver axis and gut–liver–brain axis; new findings on the clinic diagnosis of MetDs.

Dr. Meng Shi
Prof. Dr. Si Qin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • incorporation
  • redox balance
  • metabolic diseases
  • glucose and lipid metabolic disorder
  • gut microbiota
  • multi-omics

Published Papers (2 papers)

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Research

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12 pages, 2298 KiB  
Article
Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production
by Zhi-Xu Zhang, Run-Ming Mo, Dong-Bo Liu, Yi-Song Liu, Cong-Hui Liu, Yong-Shen Li, Zhong-Hua Liu and Dan Qin
Metabolites 2023, 13(6), 704; https://doi.org/10.3390/metabo13060704 - 29 May 2023
Cited by 3 | Viewed by 1340
Abstract
Ganpu vine tea is a new type of health care citrus fruit tea made from citrus shell, Pu-er tea, and vine tea baked as raw materials. In this study, the in vitro uric acid synthase inhibition system and hyperuric acid cell model were [...] Read more.
Ganpu vine tea is a new type of health care citrus fruit tea made from citrus shell, Pu-er tea, and vine tea baked as raw materials. In this study, the in vitro uric acid synthase inhibition system and hyperuric acid cell model were constructed to appraise the uric acid lowering efficacy of Ganpu vine tea, traditional Ganpu tea, and vine tea. Results showed that in the uric acid synthase inhibition system, the aqueous extract can inhibite the puric metabolically related enzymes, such as adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and xanthine oxidase (XOD). The ability of the aqueous extract to inhibit the above enzyme was as follows: vine tea > Ganpu vine tea > Ganpu tea; all teas had a strong effect on XOD inhibition. The hyperuric acid cell model test showed that the aqueous extract inhibited uric acid production through accumulating inosine and hypoxanthine and hindering xanthine synthesis. The uric acid reductive ability was as follows: Vine tea > Ganpu vine tea > Ganpu tea. The inhibition of enzymes related to uric acid synthesis and the inhibition of uric acid production were significantly enhanced through adding vine tea to Ganpu tea. It also shows that flavonoids are the main factor driving this ability because they are the main active ingredients in these botanical drinks. Full article
(This article belongs to the Special Issue Polyphenols and Metabolic Diseases)
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Review

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16 pages, 1345 KiB  
Review
The Impact of Tannic Acid Consumption on Bone Mineralization
by Anna Winiarska-Mieczan, Siemowit Muszyński, Ewa Tomaszewska, Małgorzata Kwiecień, Janine Donaldson, Agnieszka Tomczyk-Warunek and Tomasz Blicharski
Metabolites 2023, 13(10), 1072; https://doi.org/10.3390/metabo13101072 - 12 Oct 2023
Cited by 1 | Viewed by 1187
Abstract
Tannic acid (TA) is an organic compound belonging to the tannin group. Like other tannins, it has an affinity for endogenous proteins, including digestive enzymes, which can result in the reduced digestibility and absorption of nutrients. It can also form complexes with mineral [...] Read more.
Tannic acid (TA) is an organic compound belonging to the tannin group. Like other tannins, it has an affinity for endogenous proteins, including digestive enzymes, which can result in the reduced digestibility and absorption of nutrients. It can also form complexes with mineral components, reducing their absorption. In some cases, this can be beneficial, such as in the case of toxic metals, but sometimes it may have a detrimental effect on the body when it involves essential mineral components like Ca, P, Mg, Na, K, or Fe. Therefore, the impact of TA on bone health should be considered from both perspectives. This relatively short review summarizes the available information and research findings on TA, with a particular focus on its potential impact on bone health. It is worth noting that future research and clinical studies may provide more detailed and precise information on this topic, allowing for a better understanding of the role of TA in maintaining the integrity of the musculoskeletal system. Despite its brevity, this paper represents a valuable contribution to the analysis of the potential benefits and challenges associated with TA in the context of bone health. We anticipate that future research will continue along this important research line, expanding our knowledge of the influence of this compound on the skeletal system and its potential therapeutic applications. Full article
(This article belongs to the Special Issue Polyphenols and Metabolic Diseases)
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