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Metabolites
Special Issues
The Impact of Polyphenols on Metabolic Health and Disease
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The Impact of Polyphenols on Metabolic Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 731

Special Issue Editors

Prof. Dr. Si Qin

E-Mail Website
Guest Editor
College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
Interests: food precision nutrition; bioactive compounds; active health; AI
Special Issues, Collections and Topics in MDPI journals
Dr. Kozue Sakao

E-Mail Website
Guest Editor
Laboratory of Function Food and Nutrigenomics, Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-8580, Japan
Interests: functional foods; chemical synthesis; nutrigenomics

Special Issue Information

Dear Colleagues,

This Special Issue "The Impact of Polyphenols on Metabolic Health and Disease" aims to emphasize the significant role played by polyphenols in the intervention (chemoprevention or treatment) of metabolic disease. The health-promoting properties of polyphenols in various chronic metabolic diseases have garnered significant attention in recent years. The mounting evidence suggests that the ingestion of polyphenols or their metabolites can effectively modulate metabolic disease by targeting REDOX signaling pathways, inflammatory signaling pathways, gut microbiota and the "gut–X" axis. Such diseases include, but are not limited to, diabetes mellitus, hyperlipidemia, hypertension, non-alcoholic fatty liver disease (NAFLD), cardiovascular disorders, gastrointestinal dysfunction, sleep disturbances, neurodegenerative conditions and others. The focal point of this Special Issue lies in exploring the impact and intricate molecular mechanisms of polyphenols in the intervention of metabolic dysfunction at the cellular, animal or clinical level, and we also encourage research on the intersection of nutrition, food science, pharmacy, biology, artificial intelligence and other disciplines. We cordially invite you to submit recent research articles or reviews that contribute to the elucidation of cutting-edge advancements in polyphenols and their pivotal role in promoting human health.

Prof. Dr. Si Qin
Dr. Kozue Sakao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • metabolic diseases
  • molecular mechanisms
  • intervention
  • AI

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Published Papers (1 paper)

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Research

13 pages, 2210 KB  
Article
A Pilot Study on the Effects of Sweet Potato Petiole and Leaf Powder on Gut Microbiota and Aging-Related Biomarkers in an Aged Microminipig Model
by Kazuhisa Sugai, Yoshiaki Miyamoto, Toshiyuki Sato, Yoji Hakamata, Toshiyuki Murakoshi, Shou Kobayashi, Sadahiko Iwamoto and Eiji Kobayashi
Metabolites 2025, 15(11), 713; https://doi.org/10.3390/metabo15110713 - 30 Oct 2025
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Abstract
Background/Objectives: Although many healthy foods are used for elderly humans, there are no suitable animal models to test them. We reared microminipigs (MMPs) for over 10 years, establishing aged MMP models. Using this aged preclinical model, we evaluated the effects of a polyphenol-rich [...] Read more.
Background/Objectives: Although many healthy foods are used for elderly humans, there are no suitable animal models to test them. We reared microminipigs (MMPs) for over 10 years, establishing aged MMP models. Using this aged preclinical model, we evaluated the effects of a polyphenol-rich diet without sacrificing the animals. Methods: A polyphenol-rich diet containing sweet potato petioles and leaves was administered to the aged MMPs daily for one month. Changes in fecal microbiota and aging-related cells in the peripheral blood before and after administration were assessed. Results: Administration of a diet containing sweet potato petiole and leaf resulted in increased abundance of the genera Muribaculaceae, Oscillibacter, and Desulfovibrio and a decreased abundance of the genus UCG-002 within the family Oscillospiraceae. Prediction of metabolic enzyme activity from microbiota composition identified 77 enzymes significantly altered after administration. KEGG Mapper analysis of these enzymes revealed their involvement in 27 pathways. Flow cytometry analysis of peripheral blood revealed no significant differences in the proportion of ß-galactosidase-positive cells in either group. In contrast, a significant increase in the number of Ki-67-positive cells was observed in some individuals in the treatment group. However, no significant differences in Ki-67 expression were detected after stimulation with anti-CD3/CD28 antibodies. Conclusions: We established an aged MMP model to evaluate the efficacy and safety of drugs and health foods in elderly humans. Using this model, sweet potato petioles and leaves were shown to have potential as candidate materials for future health food research. Full article
(This article belongs to the Special Issue The Impact of Polyphenols on Metabolic Health and Disease)
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