Early Metabolic Dysfunction in Children and Adolescents: The Role of Oxidative Stress and Micronutrients
A Special Issue of Metabolites (ISSN 2218-1989) belonging to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 182
Editors
Interests: nutritional and metabolic diseases in childhood; obesity; metabolic syndrome; insulin resistance; clinical endocrinology; oxidative stress; selenium
Special Issues, Collections and Topics in MDPI journals
2. School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia
Interests: metabolic consequences of childhood obesity; metabolically healthy obesity; endocrine consequences of childhood obesity; metabolic syndrome in children; type 1 and type 2 diabetes in children; puberty; DSD; adrenals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic syndrome is increasingly diagnosed in children and adolescents, largely driven by the global rise in pediatric obesity and sedentary lifestyles. Early metabolic disturbances during childhood are associated with oxidative stress, chronic low-grade inflammation, insulin resistance, and early organ involvement—including metabolic liver disease.
Emerging evidence suggests that micronutrients play a crucial role in modulating oxidative balance and metabolic pathways. Deficiencies or imbalances in vitamins, trace elements, and antioxidant com-pounds may influence mitochondrial function, lipid metabolism, and inflammatory responses, poten-tially contributing to the development and progression of metabolic syndrome in pediatric populations.
This Special Issue focuses on the complex interactions between metabolic syndrome, oxidative stress, and micronutrients in children and adolescents. We welcome original research, clinical studies, and reviews addressing biomarkers of oxidative stress, micronutrient status, nutritional determinants of metabolic risk, metabolic-associated fatty liver disease, and early preventive or therapeutic strategies in pediatric populations.
By integrating clinical, biochemical, and nutritional perspectives, this Special Issue aims to improve understanding of metabolic dysfunction early in life and support strategies for prevention and early intervention.
Dr. Teofana Otilia Bizerea-Moga
Dr. Rade Vukovic
Guest Editors
Manuscript Submission Information
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Keywords
- early metabolic dysfunction
- oxidative stress
- micronutrients
- pediatric metabolic syndrome
- insulin resistance
- obesity in children and adolescents
- metabolic risk factors
- antioxidant status
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