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Special Issue "Cellular Metabolism in Neurological Disorders"
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (18 January 2023) | Viewed by 1836
Special Issue Editors
2. KU Leuven- Stem Cell Institute (SCIL), KU Leuven University, ON4 Herestraat 49 - box 804, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Interests: amyotrophic lateral sclerosis; frontotemporal Dementia; Charcot–Marie–Tooth disease; regenerative medicine; neurodegeneration; CRISPR-Cas9; translational research
Interests: neurodegeneration; amyotrophic lateral sclerosis; frontotemporal dementia; C9orf72; axonal transport; neuroinflammation
Interests: homocysteine metabolism; folate, vitamin B12 and one-carbon metabolism; regulation of S-adenosylmethionine and methylation in metabolic disorders; amino acid metabolism energy metabolism in the central nervous system; inherited disorders affecting neurotransmitter metabolism; risk factors for vascular and neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Recent years have witnessed a significant growth of evidence that show dysregulated energy metabolism in neurological disorders. Neurons are large, polarized, excitable cells and, therefore, face unique challenges to maintain energy homeostasis. As such, they are the main contributors to the huge energy demand of the central nervous system (CNS). The remarkable vulnerability of neuronal cells to energy reduction contributes to disease susceptibility and progression. In addition, mitochondrial dysfunction has been widely recognized as a typical clinical hallmark of several neurodegenerative disorders, including Huntington's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Epilepsy, Schizophrenia, Multiple sclerosis, Neuropathic pain, and Alzheimer's disease. As the energy supply center of cells, the function of mitochondria has been extensively investigated in relation to the metabolism feature of CNS. Furthermore, glycogen metabolism has also been an important implication for the functioning of the brain, especially for the cooperation between astrocytes and neurons. In this Special Issue, we welcome any original research articles, short reports, reviews, and case reports that explore the impact and mechanisms of metabolic alterations in neurological disorders and provide a forum to discuss emerging metabolism-centric therapeutic avenues.
Dr. Wenting Guo
Dr. Laura Fumagalli
Dr. Teodoro Bottiglieri
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- therapeutic targets