Cellular Metabolism in Neurological Disorders

Dear Colleagues,

Recent years have witnessed a significant growth of evidence that show dysregulated energy metabolism in neurological disorders. Neurons are large, polarized, excitable cells and, therefore, face unique challenges to maintain energy homeostasis. As such, they are the main contributors to the huge energy demand of the central nervous system (CNS). The remarkable vulnerability of neuronal cells to energy reduction contributes to disease susceptibility and progression. In addition, mitochondrial dysfunction has been widely recognized as a typical clinical hallmark of several neurodegenerative disorders, including Huntington's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Epilepsy, Schizophrenia, Multiple sclerosis, Neuropathic pain, and Alzheimer's disease. As the energy supply center of cells, the function of mitochondria has been extensively investigated in relation to the metabolism feature of CNS. Furthermore, glycogen metabolism has also been an important implication for the functioning of the brain, especially for the cooperation between astrocytes and neurons. In this Special Issue, we welcome any original research articles, short reports, reviews, and case reports that explore the impact and mechanisms of metabolic alterations in neurological disorders and provide a forum to discuss emerging metabolism-centric therapeutic avenues.

Dr. Wenting Guo
Dr. Laura Fumagalli
Dr. Teodoro Bottiglieri
Guest Editors

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