Special Issue "Pharmacology and Toxicology Metabolism of Synthetic and Natural Compounds"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".

Deadline for manuscript submissions: 10 July 2023 | Viewed by 235

Special Issue Editors

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Interests: experimental therapeutics in drugs dependence research; metabolomic profile of drug dependence models; role of neurotransmitters and neurometabolites in neurological diseases; metabolomic pathway involved in drug dependence research
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Interests: extraction, fractionation, isolation, and purification of bioactive secondary metabolites with particular emphasis on anticancer agents and herb-drug interaction assessment; de novo structure elucidation and characterization of natural product compounds; biosynthetic pathways of chemical classes derived from natural products; synthesis of natural product derivatives based on molecular docking studies; developing validated analytical methods using the isolated markers and hyphenated UPLC-PDA-MS technique for chemical finger-printing and standardization of nutraceuticals and herbal supplements

Special Issue Information

Dear Colleagues,

Metabolic alterations have been observed in several diseases/disorders. These alterations are linked to the toxicological and pharmacological effects of synthetic and natural products. It is important to establish metabolomics profiling of drugs-induced diseases and/or toxicity. This will provide beneficial information about the effects of synthetic and natural compounds on amino acids, sugars, fatty acids and other metabolites as well as metabolic signaling in different systems in the body. Moreover, drugs-induced disease models such as substances use disorders models have altered metabolomic profiles. This alteration in metabolites might be resulted from pharmacological or toxicological effects of these substances of abuse. In addition, conducting metabolic studies on natural products is critical to report the potential toxicity effects of the plant metabolites. Moreover, secondary metabolites of toxic natural products can be extracted, fractionated, isolated and purified using appropriate techniques. These secondary metabolites might have unknown toxicological and pharmacological effects. It is also important to study the molecular docking of the metabolites with the proteins using available software.    

The aim of this special issue is to highlight the potential metabolic pathways and metabolites that can be modulated by synthetic and natural compounds. We are pleased to invite you to submit your original research, literature and systematic reviews, meta-analysis, and case reports to be published in this special issue.

Dr. Fawaz Alasmari
Dr. Omer Ibrahim Fantoukh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metabolites
  • metabolism of drugs
  • metabolomic profile of drugs-induced diseases and/or toxicity
  • metabolomics profile of natural and synthetic products
  • metabolites analysis
  • isolation, and purification of bioactive secondary metabolites
  • metabolomic pathway involved in pharmacological research

Published Papers

This special issue is now open for submission.
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