Pharmacology and Toxicology Metabolism of Synthetic and Natural Compounds

Dear Colleagues,

Metabolic alterations have been observed in several diseases/disorders. These alterations are linked to the toxicological and pharmacological effects of synthetic and natural products. It is important to establish metabolomics profiling of drugs-induced diseases and/or toxicity. This will provide beneficial information about the effects of synthetic and natural compounds on amino acids, sugars, fatty acids and other metabolites as well as metabolic signaling in different systems in the body. Moreover, drugs-induced disease models such as substances use disorders models have altered metabolomic profiles. This alteration in metabolites might be resulted from pharmacological or toxicological effects of these substances of abuse. In addition, conducting metabolic studies on natural products is critical to report the potential toxicity effects of the plant metabolites. Moreover, secondary metabolites of toxic natural products can be extracted, fractionated, isolated and purified using appropriate techniques. These secondary metabolites might have unknown toxicological and pharmacological effects. It is also important to study the molecular docking of the metabolites with the proteins using available software.    

The aim of this special issue is to highlight the potential metabolic pathways and metabolites that can be modulated by synthetic and natural compounds. We are pleased to invite you to submit your original research, literature and systematic reviews, meta-analysis, and case reports to be published in this special issue.

Dr. Fawaz Alasmari
Dr. Omer Ibrahim Fantoukh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.