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Metabolites
Special Issues
Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases
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Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 2669

Special Issue Editors

Prof. Dr. Marcelo Macedo Rogero

E-Mail Website
Guest Editor
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 03828-000, Brazil
Interests: inflammation; nutrigenomics; nutrigenetics; obesity; exercise; protein metabolism; fatty acid metabolism.
Dr. Marco Antonio Hernández-Lepe

E-Mail Website
Guest Editor
Facultad de Medicina y Psicología, Universidad Autónoma Baja California, Tijuana 22390, Mexico
Interests: functional foods; nutrition; exercise physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases comprise a growing group of disorders associated with inherited and acquired errors in critical enzymes controlling metabolic pathways and homeostatic processes in health. The development of these diseases is widely recognized as being highly linked to fetal development conditions, an individual’s nutritional status, altered endocrine responses, and dietary factors. In this context, “Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases” aims to delve into the physiological factors and mechanisms that may regulate an individual towards a reduced risk of highly prevalent metabolic diseases (such as obesity, fatty liver disease, cancer, hypertension, and/or diabetes), with a particular emphasis on bioactive compounds or food metabolites that positively regulate specific processes.

The scope of this Special Issue focuses on disseminating the scientific community’s advances related to the analysis of bioactives and their metabolites, as well as the regulation of pathways or processes in metabolic disturbances. Researchers seek to uncover potential interventions or preventive measures against metabolic diseases by exploring the roles of bioactive components derived from food sources.

Prof. Dr. Marcelo Macedo Rogero
Dr. Marco Antonio Hernández-Lepe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • diseases
  • bioactive compounds
  • food
  • metabolites

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Published Papers (2 papers)

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Research

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10 pages, 489 KiB  
Article
Oral Supplementation with Betaine Powder Ameliorated High Blood Pressure in Spontaneously Hypertensive Rats
by Samanthi Wathsala Pelpolage, Rie Sasaki, Kenichiro Shimada, Taizo Nagura, Hirokatsu Uchino, Kyu-Ho Han and Michihiro Fukushima
Metabolites 2024, 14(7), 390; https://doi.org/10.3390/metabo14070390 - 18 Jul 2024
Cited by 1 | Viewed by 1640
Abstract
Supplementation of betaine is associated with improved cardiac health, potentially due to its function in re-methylation of homocysteine, an independent risk factor for cardiovascular diseases. We investigated the effects of oral betaine supplementation on blood pressure homeostasis in spontaneously hypertensive (SHR) rats and [...] Read more.
Supplementation of betaine is associated with improved cardiac health, potentially due to its function in re-methylation of homocysteine, an independent risk factor for cardiovascular diseases. We investigated the effects of oral betaine supplementation on blood pressure homeostasis in spontaneously hypertensive (SHR) rats and Wistar Kyoto (WKY) rats in an 8 week-feeding trial with control (SHR-con and WKY-con) and 1% betaine supplemented (SHR-b and WKY-b) diets. Systolic, diastolic, and mean blood pressure in the SHR-b group were significantly lower at week 8 (p = 0.013, p = 0.011, p = 0.010, respectively). Furthermore, serum nitric oxide (NO) levels were significantly (p < 0.05) improved in the WKY-b and SHR-b groups, suggesting a healthy endothelial function. Additionally, the serum angiotensin I converting enzyme level in SHR-b rats was also significantly lowered, which may have been another reason for lower blood pressure. A significantly higher non-HDL level in the SHR-b group might reflect enhanced lipid secretion into the circulation in the form of very-low-density lipoprotein (VLDL). Betaine is known for its effect on the synthesis of phosphatidylcholine, a key component of VLDL. However, the long-term net outcomes of both blood pressure lowering and serum lipid increment should be further studied. Full article
(This article belongs to the Special Issue Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases)
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Review

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21 pages, 997 KiB  
Review
Polymorphisms Involved in Insulin Resistance and Metabolic Inflammation: Influence of Nutrients and Dietary Interventions
by Graziela Biude Silva Duarte, Gabriela de Freitas Laiber Pascoal and Marcelo Macedo Rogero
Metabolites 2025, 15(4), 245; https://doi.org/10.3390/metabo15040245 - 2 Apr 2025
Viewed by 596
Abstract
Insulin resistance (IR) is a metabolic disorder characterized by an impaired response to insulin. This condition is associated with excess adiposity and metabolic inflammation, contributing to an increased risk for related chronic diseases. Single-nucleotide polymorphisms (SNPs) can affect genes related to metabolic pathways [...] Read more.
Insulin resistance (IR) is a metabolic disorder characterized by an impaired response to insulin. This condition is associated with excess adiposity and metabolic inflammation, contributing to an increased risk for related chronic diseases. Single-nucleotide polymorphisms (SNPs) can affect genes related to metabolic pathways which are related to IR and the individual response to nutrients and dietary patterns, affecting metabolic inflammation and insulin sensitivity. This narrative review explores the current evidence on interactions between genetic variants and dietary factors, specifically their effects in modulating IR and metabolic inflammation. A comprehensive search of the literature was conducted in PubMed, Google Scholar, and Web of Science, and a total of 95 articles were reviewed. The key findings reveal that SNPs in the TCF7L2, ADIPOQ, and TNF genes significantly influence metabolic responses and modulate the effects of the Mediterranean diet on biomarkers of inflammation and IR. Genotype-dependent variations in IR and inflammation biomarkers were observed in the response to different diets for SNPs in the TCF7L2, ADIPOQ, and TNF genes. Additionally, polygenic risk scores (PRSs) can also predict the response to the intake of nutrients and specific diets, and offer a promising tool for assessing genetic predisposition to IR. This review underscores the pivotal role of an individual’s genetic background in the effects of their nutrient intake and in the responses to dietetic interventions, thereby laying the foundation for personalized and effective nutritional strategies tailored to each individual’s necessity in mitigating IR and its associated risk factors for chronic diseases. Full article
(This article belongs to the Special Issue Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases)
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