Special Issue "Exploring Potential Diagnostic and Prognostic Salivary Biomarkers in Cancer Vol. 2"

Dear Colleagues,

Recently, the attention of researchers to the study of human saliva as a biofluid with unique properties and diagnostic capabilities has increased. Indeed, a new term, “salivaomics”, has been proposed, which brings together knowledge about various components in saliva, including the genome, epigenome, transcript, proteome, metabolome, and microbiome. This has led to the development of new technologies and validation of a wide range of salivary biomarkers that will soon render saliva a valuable tool in clinical practice. Particular attention is paid to the search for new biomarkers and combinations of salivary biomarkers for the early diagnosis of cancer.

Currently, the first steps are being taken towards evaluating the role of salivary biomarkers in the prognostic monitoring of cancer conditions. However, additional research investigations are required for the successful transfer of NMR-based salivary metabolomics to actual clinical use to provide diagnostic benefits for clinicians, researchers, and patients alike.

The second volume of this Special Issue of Metabolites, which follows the previous volume (https://www.mdpi.com/journal/metabolites/special_issues/salivary_biomarkers_cancer), is planned to include current research on the use of salivary biomarkers for the diagnosis and prognosis of cancer. Its major focus is to evaluate the future perspectives of reported observations acquired from metabolomics studies that focused on evaluations of the diagnosis and prognostic tracking of salivary biomarkers for both oral and non-oral (systemic) cancers, the former including head and neck cancer, and oral cavity squamous cell and oropharyngeal squamous cell carcinomas, and the latter featuring head and squamous cell, lung, breast, pancreatic and prostate cancers, among others.

Dr. Lyudmila Bel'skaya
Prof. Dr. Martin Grootveld
Guest Editors

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• salivary biomarkers
• metabolomics
• salivaomics
• diagnosis
• prognosis
• cancer