Latest Modern Developments on Oxytocin: Human and Animal Models Studies

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Psychiatry".

Deadline for manuscript submissions: closed (1 July 2022) | Viewed by 3301

Special Issue Editors

Special Issue Information

Dear Colleagues, 

Oxytocin is a nonapeptide hormone that is synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and is directly projected into other brain areas, where it acts as a neurotransmitter.

Recently, several data have suggested that beside the classical roles in parturition and milk letdown, oxytocin could play an important part in the pathophysiology of some psychiatric disorders mainly characterized by impairments in the social functioning. In this way, in this SI, we are proposing a complex interdisciplinary approach regarding (but not limited to) the effects of oxytocin administration (peripheral vs. intranasal) in the pathophysiological manifestations of some animal models of autism, schizophrenia, anxiety and depression etc on rat and zebrafish (e.g. animal models in general), and also on the human patients, as well as any other related or relevant aspects towards these.

Dr. Alin Stelian Ciobică
Dr. Romeo Dobrin
Guest Editors

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Keywords

  • oxytocin
  • intranasal
  • autism
  • schizophrenia
  • anxiety
  • depression
  • rat
  • zebrafish
  • animal models
  • human patients

Published Papers (1 paper)

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Review

20 pages, 408 KiB  
Review
Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders
by Tudor Florea, Matei Palimariciuc, Ana Caterina Cristofor, Irina Dobrin, Roxana Chiriță, Magdalena Bîrsan, Romeo Petru Dobrin and Manuela Pădurariu
Medicina 2022, 58(7), 923; https://doi.org/10.3390/medicina58070923 - 11 Jul 2022
Cited by 3 | Viewed by 2922
Abstract
Is a cyclic neuropeptide produced primarily in the hypothalamus and plays an important neuromodulatory role for other neurotransmitter systems, with an impact on behavior, response to danger, stress, and complex social interactions, such as pair bonding and child care. This narrative expert review [...] Read more.
Is a cyclic neuropeptide produced primarily in the hypothalamus and plays an important neuromodulatory role for other neurotransmitter systems, with an impact on behavior, response to danger, stress, and complex social interactions, such as pair bonding and child care. This narrative expert review examines the literature on oxytocin as a brain hormone. We focused on oxytocin structure, distribution, genetics, and the oxytocin receptor system, as well as the relationship of oxytocin with other neurotransmitters and the resulting impacts on the main psychiatric disorders. Oxytocin levels have been correlated over time with mental illness, with numerous studies focusing on oxytocin and the pathophysiology of the main psychiatric disorders, such as autism, schizophrenia, personality disorders, mood, and eating disorders. We highlight the role oxytocin plays in improving symptoms such as anxiety, depression, and social behavior, as the literature suggests. Risk factors and causes for psychiatric disorders range from genetic to environmental and social factors. Oxytocin could impact the latter, being linked with other neurotransmitter systems that are responsible for integrating different situations during the development phases of individuals. Also, these systems have an important role in how the body responds to stressors or bonding with others, helping with the creation of social support groups that could speed up recovery in many situations. Oxytocin has the potential to become a key therapeutic agent for future treatment and prevention strategies concerning the main psychiatric disorders. Full article
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