New Strategies for the Diagnosis and Treatment of Sepsis and Septic Shock

Dear Colleagues,

Sepsis is the leading cause of death due to infection, showing increasing incidence and mortality. Despite recent advances in understanding and treatment, its mortality remains unacceptably high. The dysregulated systemic inflammatory response to infection is the main factor for the manifestations of sepsis, leading to life-threatening organ failure. Clinical studies and quality improvement initiatives have highlighted that the prompt diagnosis and treatment of sepsis are fundamental for survival. Therefore, there is intense research interest in the field of novel biomarkers for the early diagnosis of sepsis and outcome prediction. Moreover, understanding the pathophysiologic mechanisms during sepsis is key for the development of successful treatments.

In this context, we launch a Special Issue of the journal Medicina, dedicated to New Strategies for the Diagnosis and Treatment of Sepsis and Septic Shock. This Special Issue will focus on novel sepsis biomarkers and new therapeutic strategies, including but not limited to: risk factors; inflammatory response during sepsis; metabolic alterations; changes in cytokines and chemokines; specific attributes of bacterial, viral, fungal and COVID-19 sepsis; new therapeutic targets; current, experimental and future treatment options including antibiotics, fluid resuscitation, vasopressors, anti-inflammatory agents (corticosteroids and immunomodulators), blood purification (cytokine adsorption) in septic shock, etc.

Updated reviews, mini-reviews, commentaries, or original research papers are welcomed for submission.

Dr. Irene Karampela
Dr. Paraskevi C. Fragkou
Guest Editors

Manuscript Submission Information

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