Novel Challenges and Personalized Treatment of Melanoma
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".
Deadline for manuscript submissions: 10 September 2026 | Viewed by 457
Special Issue Editors
Interests: melanoma; innate Immunity; inflammation
Interests: skin cancers; melanoma; immunotherapy; oncolytic virotherapy; clinical research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melanoma remains one of the most aggressive forms of skin cancer and continues to pose a significant challenge to clinicians and researchers worldwide. While early-stage disease can often be cured by surgical excision, advanced melanoma is characterized by its biological heterogeneity, complex immune interactions, and variable responses to therapy.
In recent years, the introduction of immunotherapy and targeted therapy has transformed the treatment landscape, leading to unprecedented improvements in patient outcomes. However, these advances have also revealed new challenges, including primary and acquired resistance, immune-related adverse events, and the limited efficacy of standard therapies in specific patient subgroups such as those with uveal or acral melanoma or with central nervous system involvement.
The next frontier in melanoma care lies in personalized and precision-based approaches. The integration of genomic, transcriptomic, and immunologic data into clinical decision-making holds great promise for improving patient stratification and therapeutic response prediction. Equally important is the understanding of the tumor microenvironment, spatial heterogeneity, and mechanisms of immune evasion that define disease progression and treatment outcomes.
This Special Issue, “Novel Challenges and Personalized Treatment of Melanoma,” aims to provide an overview of the latest advances and ongoing challenges in melanoma management. We invite original research articles, reviews, and short communications addressing, but not limited to, the following topics:
- Novel immunotherapeutic and targeted strategies;
- Biomarkers for therapy response and resistance;
- Tumor microenvironment and immune profiling;
- Liquid biopsy and ctDNA-based monitoring;
- Spatial and single-cell analyses in melanoma research;
- Management of rare melanoma subtypes;
- AI and digital approaches in melanoma diagnostics;
- Real-world and translational evidence in precision oncology.
By bringing together multidisciplinary perspectives, this Special Issue seeks to highlight innovative research directions and to promote a more personalized approach to melanoma diagnosis and treatment.
We warmly invite you to contribute your work and insights to this Special Issue.
Dr. Vincas Urbonas
Dr. Egle Ramelyte
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- melanoma
- personalized treatment
- biomarkers
- immune checkpoint inhibitors
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