Recent Innovations in Dental Implantology: Clinical Applications and Regenerative Approaches

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 761

Special Issue Editors


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Guest Editor
Department of Clinical Science and Odontostomatology, Polytechnic University of Marche, 60131 Ancona, Italy
Interests: advanced biomedical imaging; tissue physiopathology; tissue engineering and regenerative medicine (research focused on tissue physiopathology, tissue engineering and regenerative medicine)
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Guest Editor Assistant
Department of Oral Rehabilitation and Dental Emergencies, School of Dental Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: photobiomodulation; bone regeneration; lasers; dental implants (holding a doctorate and numerous scientific publications in the field of laser radiation as well as bone regeneration and repair)

Special Issue Information

Dear Colleagues,

Despite being highly developed and extensively studied, the domain of oral implantology, now integrated on a daily basis into the concept of oral rehabilitation, still leaves many ”open doors”, particularly concerning factors that influence long-term outcomes. The medical and research community is navigating a complex path that balances traditional and digital protocols, integrates innovative AI techniques into healthcare practices, and seeks to manage risk factors more effectively, all in pursuit of optimal, long-lasting outcomes by means of a combination of biology and technology.

Alongside advancements in technologies and implantology in complex medical scenarios or among patients with various chronic conditions, it represents a significant area of interest that remains insufficiently explored and understood.

This Special Issue of Medicina seeks to showcase the most recent innovations and research findings that improve biological integration, clinical protocols, and long-term success rates, even in complex clinical scenarios and in the presence of comorbidities.

We invite submissions of original research articles and reviews that focus on recent advancements in this fast-evolving domain. Areas of interest include, but are not limited to, the following:

  • Biology of the bone–implant interface and osseointegration;
  • Regenerative techniques and tissue engineering methods;
  • Growth factors and bioactive molecules in peri-implant healing;
  • Digital processes, CAD/CAM technologies, and 3D printing in the field of implantology;
  • Artificial intelligence in dental implantology;
  • Intraoral scanning, advanced imaging, and AI-assisted diagnostics;
  • Augmented reality and navigation systems in implant placement;
  • Clinical effectiveness, complications, and long-term results;
  • Immediate vs. delayed implant placement and loading;
  • Minimally invasive and flapless surgical techniques;
  • Soft tissue management and esthetic outcomes;
  • Implant success, survival rates, and complications;
  • Long-term clinical outcomes and patient-reported measures;
  • Implant therapy in medically compromised or aging populations;
  • Peri-implantitis prevention and regenerative therapies.

This Special Issue aims to highlight recent progress in the diagnosis, treatment planning, and clinical management of patients undergoing dental implant therapy, with a focus on translational approaches that bridge research and clinical practice. Contributions addressing evidence-based clinical protocols, patient-centered approaches, and innovations in regenerative and reconstructive dental medicine are particularly encouraged.

The Guest Editors bring extensive expertise in clinical and dental medicine, oral surgery, and regenerative medicine, ensuring that the Special Issue maintains a strong clinical orientation aligned with the journal’s focus on dentistry and oral health.

By bringing together current clinical insights and translational research, this Special Issue seeks to provide a comprehensive perspective on the future directions of dental implantology in modern practice.

Dr. Alessandra Giuliani
Guest Editor

Dr. Ruxandra Elena Luca
Guest Editor Assistant

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental implants
  • bone augmentation
  • regenerative techniques
  • digital and AI-assisted workflow
  • advanced imaging
  • osseointegration
  • surgical complications
  • peri-implant disease management
  • soft tissue management

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Published Papers (1 paper)

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Research

11 pages, 569 KB  
Article
Quality of Life Following Dental Rehabilitation with Customized Subperiosteal Implants: A Pilot Cohort Study
by Evangelos Kostares, Michael Kostares, Georgia Kostare, Fani Pitsigavdaki, Ourania Schoinohoriti and Christos Perisanidis
Medicina 2026, 62(4), 777; https://doi.org/10.3390/medicina62040777 - 16 Apr 2026
Viewed by 363
Abstract
Background and Objectives: Severe alveolar atrophy may pose significant challenges for dental rehabilitation. Recent advances in digital planning and CAD/CAM technology have renewed the interest in patient-specific subperiosteal implants as a treatment option for anatomically challenging cases. This cohort study evaluated changes [...] Read more.
Background and Objectives: Severe alveolar atrophy may pose significant challenges for dental rehabilitation. Recent advances in digital planning and CAD/CAM technology have renewed the interest in patient-specific subperiosteal implants as a treatment option for anatomically challenging cases. This cohort study evaluated changes in oral health-related quality of life and patient satisfaction following rehabilitation with customized subperiosteal implants in severe alveolar atrophy. Materials and Methods: This cohort study included all consecutive adult patients with severe alveolar atrophy who underwent reconstruction with patient-specific subperiosteal implants at the Department of Oral and Maxillofacial Surgery of “Evangelismos” General Hospital, Athens, Greece, in 2025. Oral health-related quality of life was assessed using the validated OHIP-14 questionnaire preoperatively and 12 months postoperatively. Patient satisfaction was evaluated using a numerical rating scale (NRS). Secondary outcomes included postoperative complications, implant exposure, implant stability, and need for reoperation. Comparisons between baseline and 12-month scores were performed using the Wilcoxon signed-rank test. Results: Nine patients who had completed 12-month follow-up were included. Five were male, and all implants were placed in the maxilla. Significant improvement was observed in oral health-related quality of life, with the median OHIP-14 total score decreasing from 41 preoperatively to 1 at the 12-month follow-up. Patient satisfaction also improved significantly, with the median NRS total score increasing from 17 to 58. Improvements were consistent across all OHIP-14 domains and all NRS items. No major complications were recorded. One patient developed early wound dehiscence, and one patient presented with implant exposure at the anterior palate. At the final follow-up twelve months postoperatively, all implants remained clinically and radiographically stable. Conclusions: These preliminary short-term findings suggest that customized subperiosteal implants may be a promising option for selected patients with severe alveolar atrophy in whom placement of conventional endosseous implants is not feasible; however, the results should be interpreted cautiously given the very small sample size and observational design. Full article
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