Recent Innovations in Dental Implantology: Clinical Applications and Regenerative Approaches

Dear Colleagues,

Despite being highly developed and extensively studied, the domain of oral implantology, now integrated on a daily basis into the concept of oral rehabilitation, still leaves many ”open doors”, particularly concerning factors that influence long-term outcomes. The medical and research community is navigating a complex path that balances traditional and digital protocols, integrates innovative AI techniques into healthcare practices, and seeks to manage risk factors more effectively, all in pursuit of optimal, long-lasting outcomes by means of a combination of biology and technology.

Alongside advancements in technologies and implantology in complex medical scenarios or among patients with various chronic conditions, it represents a significant area of interest that remains insufficiently explored and understood.

This Special Issue of Medicina seeks to showcase the most recent innovations and research findings that improve biological integration, clinical protocols, and long-term success rates, even in complex clinical scenarios and in the presence of comorbidities.

We invite submissions of original research articles and reviews that focus on recent advancements in this fast-evolving domain. Areas of interest include, but are not limited to, the following:

• Biology of the bone–implant interface and osseointegration;
• Regenerative techniques and tissue engineering methods;
• Growth factors and bioactive molecules in peri-implant healing;
• Digital processes, CAD/CAM technologies, and 3D printing in the field of implantology;
• Artificial intelligence in dental implantology;
• Intraoral scanning, advanced imaging, and AI-assisted diagnostics;
• Augmented reality and navigation systems in implant placement;
• Clinical effectiveness, complications, and long-term results;
• Immediate vs. delayed implant placement and loading;
• Minimally invasive and flapless surgical techniques;
• Soft tissue management and esthetic outcomes;
• Implant success, survival rates, and complications;
• Long-term clinical outcomes and patient-reported measures;
• Implant therapy in medically compromised or aging populations;
• Peri-implantitis prevention and regenerative therapies.

This Special Issue aims to highlight recent progress in the diagnosis, treatment planning, and clinical management of patients undergoing dental implant therapy, with a focus on translational approaches that bridge research and clinical practice. Contributions addressing evidence-based clinical protocols, patient-centered approaches, and innovations in regenerative and reconstructive dental medicine are particularly encouraged.

The Guest Editors bring extensive expertise in clinical and dental medicine, oral surgery, and regenerative medicine, ensuring that the Special Issue maintains a strong clinical orientation aligned with the journal’s focus on dentistry and oral health.

By bringing together current clinical insights and translational research, this Special Issue seeks to provide a comprehensive perspective on the future directions of dental implantology in modern practice.

Dr. Alessandra Giuliani
Guest Editor

Dr. Ruxandra Elena Luca
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• dental implants
• bone augmentation
• regenerative techniques
• digital and AI-assisted workflow
• advanced imaging
• osseointegration
• surgical complications
• peri-implant disease management
• soft tissue management